DegronMD - Q8WYN3(CSRNP3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T49P	TCGA-05-4395	LUAD	TCGA	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.25
p.T49P	DO25444	LUAD	ICGC	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.25
p.H298Q	TCGA-15-1446	GBM	TCGA	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.647
p.H298Q	DO12490	GBM	ICGC	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.647
p.A306T	TCGA-2W-A8YY	CESC	TCGA	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1944
p.A306T	DO223732	CESC	ICGC	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1944
p.S43P	TCGA-50-5933	LUAD	TCGA	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation altering degron motif	0.5641
p.S43P	DO24800	LUAD	ICGC	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation altering degron motif	0.5641
p.P304H	TCGA-77-7335	LUSC	TCGA	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.25
p.P304H	TCGA-A5-A0G1	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.25
p.P304H	DO26707	LUSC	ICGC	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.25
p.P304H	DO42472	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.25
p.P304H	SIDM00721	Small Cell Lung Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.25
p.P304H	NCI-H250	lung	COSMIC	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.25
p.V309I	TCGA-AD-5900	COAD	TCGA	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1111
p.V309I	TCGA-BR-6706	STAD	TCGA	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1111
p.V309I	DO8514	COAD	ICGC	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1111
p.V309I	DO38211	STAD	ICGC	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1111
p.P50S	TCGA-B5-A0JY	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.2222
p.P50S	DO43041	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.2222
p.S301F	TCGA-BR-8680	STAD	TCGA	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.7982
p.S301F	DO47769	STAD	ICGC	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.7982
p.S33R	TCGA-CD-5801	STAD	TCGA	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.0833
p.S33R	DO38563	STAD	ICGC	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.0833
p.S52C	TCGA-DK-A3IT	BLCA	TCGA	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1667
p.S52C	DO779	BLCA	ICGC	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1667
p.D35G	TCGA-FI-A2D5	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1389
p.D35G	DO41331	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1389
p.L288M	TCGA-IB-7651	PAAD	TCGA	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.0833
p.L288M	DO46657	PAAD	ICGC	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.0833
p.C291R	TCGA-WS-AB45	COAD	TCGA	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1667
p.C291R	DO51734	COAD	ICGC	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.1667
p.A32V	DO233116	GACA	ICGC	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.0556
p.A32V	U-2-OS	bone	COSMIC	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.0556
p.D38G	DO233869	GACA	ICGC	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.2222
p.A297S	DO228948	LICA	ICGC	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation altering degron motif	0.7588
p.A34V	DO48709	LIRI	ICGC	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1111
p.P42L	DO222536	MELA	ICGC	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation altering degron motif	0.7582
p.F48L	SIDM00417	Plasma Cell Myeloma	GDSC	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.2778
p.F48L	U-266	haematopoietic and lymphoid tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.2778
p.T287M	SIDM00217	Colorectal Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.0556
p.T287M	SNU-1040	large intestine	COSMIC	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.0556
p.R295H	ACH-000261	Lung Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.2778
p.R295H	ACH-002122	Lung Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.2778
p.H302Q	ACH-001561	Lung Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	297:301	Mutation rewiring degron network	0.3056

Kaplan plot for CSRNP3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CSRNP3

UniProt ID: Q8WYN3

Entrez ID: 80034

Protein name: Cysteine/serine-rich nuclear protein 3 (CSRNP-3) (Protein FAM130A2) (TGF-beta-induced apoptosis protein 2) (TAIP-2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CSRNP3 in