DegronMD

Uniprot ID: Q13586

Source protein: Stromal interaction molecule 1

Source gene: STIM1

Class: DEG_SPOP_SBC_1

Location: 397:401

E3 ligase: SPOP

DEGRON score: 0.9518

ASA_SCORE: 53.5

COIL: 0.7156

CONS_SCORE: 0.6281

DSS_SCORE: 0.1998

HELIX: 0.1628

FCONS_SCORE: 1.0478

RIG_SCORE: 0.7305

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V396M	TCGA-AX-A0J1	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.3056
p.L402R	TCGA-DW-7963	KIRP	TCGA	AHSSS	DEG_SPOP_SBC_1	0.3056
p.H395Y	TCGA-44-2656	LUAD	TCGA	AHSSS	DEG_SPOP_SBC_1	0.2778
p.K408Q	TCGA-D3-A2JF	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	0.25

Showing 1 to 4 of 4 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	464:468	AHSSS	SPOP	0.8527	More...
Q8WYN3	Cysteine/serine-rich nuclear protein 3	DEG_SPOP_SBC_1	297:301	AHSSS	SPOP	0.8601	More...
Q2WGJ9	Fer-1-like protein 6	DEG_SPOP_SBC_1	1123:1127	AHSSS	SPOP	0.7335	More...
O60269	G protein-regulated inducer of neurite outgrowth 2	DEG_SPOP_SBC_1	206:210	AHSSS	SPOP	0.855	More...
A6NMT0	Homeobox protein DBX1	DEG_SPOP_SBC_1	314:318	AHSSS	SPOP	0.9343	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SPOP_SBC_1	1445:1449	AHSSS	SPOP	0.9988	More...
Q05952	Nuclear transition protein 2	DEG_SPOP_SBC_1	62:66	AHSSS	SPOP	0.9869	More...
Q13416	Origin recognition complex subunit 2	DEG_SPOP_SBC_1	246:250	AHSSS	SPOP	0.8711	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	211:215	AHSSS	SPOP	0.5387	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	422:426	AHSSS	SPOP	0.9446	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	694:698	AHSSS	SPOP	0.9817	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	76:80	AHSSS	SPOP	0.9484	More...
C9J798	Ras GTPase-activating protein 4B	DEG_SPOP_SBC_1	782:786	AHSSS	SPOP	0.6288	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_SPOP_SBC_1	498:502	AHSSS	SPOP	0.9472	More...
Q13586	Stromal interaction molecule 1	DEG_SPOP_SBC_1	397:401	AHSSS	SPOP	0.9518	More...
O95425	Supervillin	DEG_SPOP_SBC_1	249:253	AHSSS	SPOP	0.9277	More...
O15015	Zinc finger protein 646	DEG_SPOP_SBC_1	903:907	AHSSS	SPOP	0.9691	More...

Showing 1 to 17 of 17 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons