DegronMD - Q9ULI4(KIF26A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G175V	TCGA-A5-A1OF	UCEC	TCGA	PPSTT	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.1111
p.G175V	DO42568	UCEC	ICGC	PPSTT	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.1111
p.A154T	TCGA-D5-6930	COAD	TCGA	PPSTT	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.0833
p.A154T	DO10550	COAD	ICGC	PPSTT	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.0833
p.A1226G	TCGA-DK-AA6T	BLCA	TCGA	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation rewiring degron network	0.0833
p.A1226G	DO51872	BLCA	ICGC	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation rewiring degron network	0.0833
p.S1447I	TCGA-DU-6392	LGG	TCGA	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.7341
p.S1447I	DO22237	LGG	ICGC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.7341
p.K731N	TCGA-EO-A3AV	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.2778
p.K731N	DO52412	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.2778
p.A730T	TCGA-EY-A1GU	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.25
p.A730T	DO41518	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.25
p.E1442K	TCGA-FR-A726	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation rewiring degron network	0.25
p.E1442K	DO48665	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation rewiring degron network	0.25
p.R1227H	TCGA-GV-A3JX	BLCA	TCGA	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation rewiring degron network	0.1111
p.R1227H	DO448	BLCA	ICGC	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation rewiring degron network	0.1111
p.R1227H	DO7340	CLLE	ICGC	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation rewiring degron network	0.1111
p.R1227H	DO227604	PACA	ICGC	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation rewiring degron network	0.1111
p.A1226T	TCGA-IB-7651	PAAD	TCGA	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation rewiring degron network	0.0833
p.A1226T	DO46657	PAAD	ICGC	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation rewiring degron network	0.0833
p.P1459T	TCGA-MP-A4TK	LUAD	TCGA	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation rewiring degron network	0.0556
p.P1459T	DO45384	LUAD	ICGC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation rewiring degron network	0.0556
p.R1227G	TCGA-XF-AAMX	BLCA	TCGA	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation rewiring degron network	0.1111
p.R1227G	DO51939	BLCA	ICGC	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation rewiring degron network	0.1111
p.G1595S	DO218182	BRCA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	1589:1594	Mutation rewiring degron network	0.3056
p.G1595S	DO222363	MELA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	1589:1594	Mutation rewiring degron network	0.3056
p.T173M	DO52714	CLLE	ICGC	PPSTT	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.1667
p.R1307Q	DO233652	GACA	ICGC	VTTPAVS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.1111
p.S1447N	DO233885	GACA	ICGC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.7069
p.R726L	DO228974	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.1389
p.R726L	DO229027	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.1389
p.R726L	DO229026	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.1389
p.R726L	DO229031	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.1389
p.A1436S	DO228985	LICA	ICGC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation rewiring degron network	0.0833
p.S1231N	DO23174	LINC	ICGC	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation blocking phosphorylation signal	0.6667
p.G1314V	DO25320	LUAD	ICGC	VTTPAVS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.3056
p.G746V	DO230998	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.0833
p.G746V	DO224576	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.0833
p.G175R	DO220903	MELA	ICGC	PPSTT	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.1111
p.A1586V	DO233297	NACA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	1589:1594	Mutation rewiring degron network	0.25
p.A1586V	SIDM00693	Bladder Carcinoma	GDSC	DSGHDS	DEG_SCF_TRCP1_1	1589:1594	Mutation rewiring degron network	0.25
p.A1586V	SIDM01732	Non-Cancerous	GDSC	DSGHDS	DEG_SCF_TRCP1_1	1589:1594	Mutation rewiring degron network	0.25
p.P1233T	DO50712	ORCA	ICGC	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation rewiring degron network	0.2778
p.R726H	DO232761	PBCA	ICGC	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.1389
p.S170L	DO232224	PBCA	ICGC	PPSTT	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.25
p.S1594R	DO232599	PBCA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	1589:1594	Mutation altering degron motif	0.7427
p.P1459S	DO229462	SKCA	ICGC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation rewiring degron network	0.0556
p.E740K	DO218874	SKCA	ICGC	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.25
p.P1458L	DO218898	SKCA	ICGC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation rewiring degron network	0.0833
p.G1584S	DO37425	SKCM	ICGC	DSGHDS	DEG_SCF_TRCP1_1	1589:1594	Mutation rewiring degron network	0.1944
p.R1452P	DO229151	THCA	ICGC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation rewiring degron network	0.25
p.V1315A	DO229253	THCA	ICGC	VTTPAVS	DEG_SCF_FBW7_1	1315:1321	Mutation altering degron motif	0.6936
p.R726C	SIDM02046	Pancreatic Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.1389
p.R726C	SIDM00680	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.1389
p.R726C	SIDM00945	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.1389
p.R726C	SIDM01464	Pancreatic Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.1389
p.R1235C	SIDM01962	Colorectal Carcinoma	GDSC	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation altering degron motif	0.8301
p.A177V	SIDM00629	Breast Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.0556
p.A177V	MDA-MB-436	breast	COSMIC	PPSTT	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.0556
p.P155L	SIDM01079	Melanoma	GDSC	PPSTT	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.1111
p.P155L	ACH-000441	Skin Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.1111
p.P155L	SH-4	skin	COSMIC	PPSTT	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.1111
p.A1445V	SIDM00335	Endometrial Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.5825
p.A1445V	SIDM00217	Colorectal Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.5825
p.A1445V	SNU-1040	large intestine	COSMIC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.5825
p.A1445V	MFE-280	endometrium	COSMIC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.5825
p.C1250Y	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation rewiring degron network	0.0833
p.C1250Y	ACH-000787	Lung Cancer	CCLE	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation rewiring degron network	0.0833
p.C1250Y	LXF-289	lung	COSMIC	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation rewiring degron network	0.0833
p.E1328G	SIDM00954	Breast Carcinoma	GDSC	VTTPAVS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.1389
p.S1437F	SIDM01077	Prostate Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation blocking phosphorylation signal	0.5556
p.S1437F	ACH-000115	Prostate Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation blocking phosphorylation signal	0.5556
p.S1437F	VCaP	prostate	COSMIC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation blocking phosphorylation signal	0.5556
p.A1436P	SIDM01105	Melanoma	GDSC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation rewiring degron network	0.0833
p.A1436P	ACH-000423	Skin Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation rewiring degron network	0.0833
p.A1436P	SK-MEL-3	skin	COSMIC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation rewiring degron network	0.0833
p.P1305L	SIDM00839	Colorectal Carcinoma	GDSC	VTTPAVS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.0556
p.P1305L	ACH-000950	Colon/Colorectal Cancer	CCLE	VTTPAVS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.0556
p.S1448I	SIDM01318	Hepatocellular Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.7341
p.S1448I	ACH-001318	Liver Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.7341
p.S1448N	SIDM01617	Endometrial Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.7069
p.S1448N	ACH-000994	Endometrial/Uterine Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.7069
p.T1317M	SIDM01368	Gastric Carcinoma	GDSC	VTTPAVS	DEG_SCF_FBW7_1	1315:1321	Mutation altering degron motif	0.7423
p.S160I	SIDM01611	Endometrial Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.25
p.S160I	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.25
p.T1327K	ACH-000752	Lung Cancer	CCLE	VTTPAVS	DEG_SCF_FBW7_1	1315:1321	Mutation blocking phosphorylation signal	0.6111
p.R724C	ACH-000955	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.0833
p.C1225Y	ACH-002511	Skin Cancer	CCLE	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation rewiring degron network	0.0556
p.R1321L	NCI-H650	lung	COSMIC	VTTPAVS	DEG_SCF_FBW7_1	1315:1321	Mutation altering degron motif	0.8428
p.A162T	SNU-1040	large intestine	COSMIC	PPSTT	DEG_SPOP_SBC_1	163:167	Mutation rewiring degron network	0.3056
p.A1306V	SNU-1040	large intestine	COSMIC	VTTPAVS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.0833
p.A1306V	MFE-280	endometrium	COSMIC	VTTPAVS	DEG_SCF_FBW7_1	1315:1321	Mutation rewiring degron network	0.0833
p.A730P	A101D	skin	COSMIC	ASSSS	DEG_SPOP_SBC_1	733:737	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF26A

UniProt ID: Q9ULI4

Entrez ID: 26153

Protein name: Kinesin-like protein KIF26A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF26A in