DegronMD - Q9ULI4(KIF26A)

FUNCTION: Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). {ECO:0000250}.

GO - Biological processes (BP): enteric nervous system development [GO:0048484]; negative regulation of signal transduction [GO:0009968]; regulation of cell growth by extracellular stimulus [GO:0001560]

GO - Molecular function (MF): ATP binding [GO:0005524]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]

GO - Cellular component (CC): cytosol [GO:0005829]; kinesin complex [GO:0005871]; microtubule [GO:0005874]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1321L	NCI-H650	lung	COSMIC	VTTPAVS	DEG_SCF_FBW7_1	1315:1321	Mutation altering degron motif	0.8428
p.R1235C	SIDM01962	Colorectal Carcinoma	GDSC	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation altering degron motif	0.8301
p.S1594R	DO232599	PBCA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	1589:1594	Mutation altering degron motif	0.7427
p.T1317M	SIDM01368	Gastric Carcinoma	GDSC	VTTPAVS	DEG_SCF_FBW7_1	1315:1321	Mutation altering degron motif	0.7423
p.S1447I	TCGA-DU-6392	LGG	TCGA	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.7341
p.S1447I	DO22237	LGG	ICGC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.7341
p.S1448I	SIDM01318	Hepatocellular Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.7341
p.S1448I	ACH-001318	Liver Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.7341
p.S1447N	DO233885	GACA	ICGC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.7069
p.S1448N	SIDM01617	Endometrial Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.7069
p.S1448N	ACH-000994	Endometrial/Uterine Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.7069
p.V1315A	DO229253	THCA	ICGC	VTTPAVS	DEG_SCF_FBW7_1	1315:1321	Mutation altering degron motif	0.6936
p.S1231N	DO23174	LINC	ICGC	RGGLFED	LIG_APCC_ABBAyCdc20_2	1235:1241	Mutation blocking phosphorylation signal	0.6667
p.T1327K	ACH-000752	Lung Cancer	CCLE	VTTPAVS	DEG_SCF_FBW7_1	1315:1321	Mutation blocking phosphorylation signal	0.6111
p.A1445V	SIDM00335	Endometrial Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.5825
p.A1445V	SIDM00217	Colorectal Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.5825
p.A1445V	SNU-1040	large intestine	COSMIC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.5825
p.A1445V	MFE-280	endometrium	COSMIC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation altering degron motif	0.5825
p.S1437F	SIDM01077	Prostate Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation blocking phosphorylation signal	0.5556
p.S1437F	ACH-000115	Prostate Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	1445:1449	Mutation blocking phosphorylation signal	0.5556

Showing 1 to 20 of 93 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF26A

UniProt ID: Q9ULI4

Entrez ID: 26153

Protein name: Kinesin-like protein KIF26A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF26A in