DegronMD

Uniprot ID: Q9ULI4

Source protein: Kinesin-like protein KIF26A

Source gene: KIF26A

Class: LIG_APCC_ABBAyCdc20_2

Location: 1235:1241

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9918

ASA_SCORE: 78.7429

COIL: 0.8421

CONS_SCORE: 0.3293

DSS_SCORE: 0.499

HELIX: 0.0477

FCONS_SCORE: 1.1025

RIG_SCORE: 0.7065

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1226G	TCGA-DK-AA6T	BLCA	TCGA	RGGLFED	LIG_APCC_ABBAyCdc20_2	0.0833
p.A1226G	DO51872	BLCA	ICGC	RGGLFED	LIG_APCC_ABBAyCdc20_2	0.0833
p.R1227H	TCGA-GV-A3JX	BLCA	TCGA	RGGLFED	LIG_APCC_ABBAyCdc20_2	0.1111
p.R1227H	DO448	BLCA	ICGC	RGGLFED	LIG_APCC_ABBAyCdc20_2	0.1111
p.R1227H	DO7340	CLLE	ICGC	RGGLFED	LIG_APCC_ABBAyCdc20_2	0.1111
p.R1227H	DO227604	PACA	ICGC	RGGLFED	LIG_APCC_ABBAyCdc20_2	0.1111
p.A1226T	TCGA-IB-7651	PAAD	TCGA	RGGLFED	LIG_APCC_ABBAyCdc20_2	0.0833
p.A1226T	DO46657	PAAD	ICGC	RGGLFED	LIG_APCC_ABBAyCdc20_2	0.0833
p.R1227G	TCGA-XF-AAMX	BLCA	TCGA	RGGLFED	LIG_APCC_ABBAyCdc20_2	0.1111
p.R1227G	DO51939	BLCA	ICGC	RGGLFED	LIG_APCC_ABBAyCdc20_2	0.1111
p.S1231N	DO23174	LINC	ICGC	RGGLFED	LIG_APCC_ABBAyCdc20_2	0.6667
p.P1233T	DO50712	ORCA	ICGC	RGGLFED	LIG_APCC_ABBAyCdc20_2	0.2778
p.R1235C	SIDM01962	Colorectal Carcinoma	GDSC	RGGLFED	LIG_APCC_ABBAyCdc20_2	0.8301
p.C1250Y	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	RGGLFED	LIG_APCC_ABBAyCdc20_2	0.0833
p.C1250Y	ACH-000787	Lung Cancer	CCLE	RGGLFED	LIG_APCC_ABBAyCdc20_2	0.0833
p.C1250Y	LXF-289	lung	COSMIC	RGGLFED	LIG_APCC_ABBAyCdc20_2	0.0833
p.C1225Y	ACH-002511	Skin Cancer	CCLE	RGGLFED	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULI4	Kinesin-like protein KIF26A	LIG_APCC_ABBAyCdc20_2	1235:1241	RGGLFED	APC,CDC20,FZR1	0.9918	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons