DegronMD

Uniprot ID: Q9ULI4

Source protein: Kinesin-like protein KIF26A

Source gene: KIF26A

Class: DEG_SCF_FBW7_1

Location: 1315:1321

E3 ligase: FBXW7

DEGRON score: 0.9424

ASA_SCORE: 66.2

COIL: 0.651

CONS_SCORE: 0.2917

DSS_SCORE: 0.4206

HELIX: 0.037

FCONS_SCORE: 0.9022

RIG_SCORE: 0.7534

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1307Q	DO233652	GACA	ICGC	VTTPAVS	DEG_SCF_FBW7_1	0.1111
p.G1314V	DO25320	LUAD	ICGC	VTTPAVS	DEG_SCF_FBW7_1	0.3056
p.V1315A	DO229253	THCA	ICGC	VTTPAVS	DEG_SCF_FBW7_1	0.6936
p.E1328G	SIDM00954	Breast Carcinoma	GDSC	VTTPAVS	DEG_SCF_FBW7_1	0.1389
p.P1305L	SIDM00839	Colorectal Carcinoma	GDSC	VTTPAVS	DEG_SCF_FBW7_1	0.0556
p.P1305L	ACH-000950	Colon/Colorectal Cancer	CCLE	VTTPAVS	DEG_SCF_FBW7_1	0.0556
p.T1317M	SIDM01368	Gastric Carcinoma	GDSC	VTTPAVS	DEG_SCF_FBW7_1	0.7423
p.T1327K	ACH-000752	Lung Cancer	CCLE	VTTPAVS	DEG_SCF_FBW7_1	0.6111
p.R1321L	NCI-H650	lung	COSMIC	VTTPAVS	DEG_SCF_FBW7_1	0.8428
p.A1306V	SNU-1040	large_intestine	COSMIC	VTTPAVS	DEG_SCF_FBW7_1	0.0833
p.A1306V	MFE-280	endometrium	COSMIC	VTTPAVS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULI4	Kinesin-like protein KIF26A	DEG_SCF_FBW7_1	1315:1321	VTTPAVS	FBXW7	0.9424	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons