DegronMD

Uniprot ID: Q9ULI4

Source protein: Kinesin-like protein KIF26A

Source gene: KIF26A

Class: DEG_SCF_TRCP1_1

Location: 1589:1594

E3 ligase: BTRC

DEGRON score: 0.9927

ASA_SCORE: 79.4333

COIL: 0.8002

CONS_SCORE: 0.4127

DSS_SCORE: 0.6892

HELIX: 0.1335

FCONS_SCORE: 1.1185

RIG_SCORE: 0.5316

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1594R	DO232599	PBCA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.7427
p.G1595S	DO218182	BRCA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.3056
p.G1595S	DO222363	MELA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.3056
p.A1586V	DO233297	NACA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.25
p.A1586V	SIDM00693	Bladder Carcinoma	GDSC	DSGHDS	DEG_SCF_TRCP1_1	0.25
p.A1586V	SIDM01732	Non-Cancerous	GDSC	DSGHDS	DEG_SCF_TRCP1_1	0.25
p.G1584S	DO37425	SKCM	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.1944

Showing 1 to 7 of 7 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ86	E3 ubiquitin-protein ligase TRIM36	DEG_SCF_TRCP1_1	615:620	DSGHDS	BTRC	0.8094	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SCF_TRCP1_1	1589:1594	DSGHDS	BTRC	0.9927	More...
Q7Z4K8	Tripartite motif-containing protein 46	DEG_SCF_TRCP1_1	633:638	DSGHDS	BTRC	0.809	More...
Q495M9	Usher syndrome type-1G protein	DEG_SCF_TRCP1_1	300:305	DSGHDS	BTRC	0.9169	More...

Showing 1 to 4 of 4 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons