DegronMD - Q495M9(USH1G)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A286V	TCGA-06-0152	GBM	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0556
p.A286V	DO11238	GBM	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0556
p.L312M	TCGA-44-3398	LUAD	TCGA	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.711
p.L312M	DO25030	LUAD	ICGC	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.711
p.F276L	TCGA-AA-3984	COAD	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.587
p.F276L	DO9002	COAD	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.587
p.R318C	TCGA-AG-A01W	READ	TCGA	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.2778
p.R318C	DO36382	READ	ICGC	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.2778
p.E280K	TCGA-B5-A0JY	UCEC	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.2222
p.E280K	DO43041	UCEC	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.2222
p.A262T	TCGA-B5-A11L	UCEC	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1667
p.A262T	DO42961	UCEC	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1667
p.R318H	TCGA-B5-A3FC	UCEC	TCGA	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.2778
p.R318H	TCGA-DF-A2KN	UCEC	TCGA	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.2778
p.R318H	DO223282	UCEC	ICGC	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.2778
p.R318H	DO41871	UCEC	ICGC	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.2778
p.R273L	TCGA-BF-A1Q0	SKCM	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.7316
p.R273L	DO47374	SKCM	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.7316
p.G302D	TCGA-D7-A4YY	STAD	TCGA	DSGHDS	DEG_SCF_TRCP1_1	300:305	Mutation altering degron motif	0.7198
p.G302D	DO47733	STAD	ICGC	DSGHDS	DEG_SCF_TRCP1_1	300:305	Mutation altering degron motif	0.7198
p.R285S	TCGA-DF-A2KN	UCEC	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0833
p.R285S	DO223282	UCEC	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0833
p.V316A	TCGA-DU-6392	LGG	TCGA	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.5825
p.V316A	DO22237	LGG	ICGC	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.5825
p.N263I	TCGA-EE-A2GR	SKCM	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1944
p.N263I	DO37996	SKCM	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1944
p.L277F	TCGA-EE-A2M8	SKCM	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.3056
p.L277F	DO38075	SKCM	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.3056
p.T260A	TCGA-FS-A1ZT	SKCM	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1111
p.T260A	DO37468	SKCM	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1111
p.M315T	TCGA-NC-A5HO	LUSC	TCGA	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.7423
p.M315T	TCGA-VQ-A91E	STAD	TCGA	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.7423
p.M315T	DO219197	LUSC	ICGC	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.7423
p.M315T	DO51784	STAD	ICGC	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.7423
p.D304V	TCGA-VQ-A8PP	STAD	TCGA	DSGHDS	DEG_SCF_TRCP1_1	300:305	Mutation altering degron motif	0.6674
p.D304V	DO51774	STAD	ICGC	DSGHDS	DEG_SCF_TRCP1_1	300:305	Mutation altering degron motif	0.6674
p.P310H	TCGA-WS-AB45	COAD	TCGA	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.6583
p.P310H	DO51734	COAD	ICGC	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.6583
p.S295L	DO233203	GACA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	300:305	Mutation rewiring degron network	0.1944
p.T308N	DO228390	LICA	ICGC	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.5944
p.Y261N	DO228848	LICA	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1389
p.A293D	DO229027	LICA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	300:305	Mutation rewiring degron network	0.1389
p.S298R	DO229006	LICA	ICGC	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.0556
p.S298R	DO229006	LICA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	300:305	Mutation rewiring degron network	0.2778
p.W267R	DO52664	MALY	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.3056
p.G259S	DO222837	MELA	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0833
p.G259S	SIDM00422	Hodgkin's Lymphoma	GDSC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0833
p.G259S	ACH-001203	Lymphoma	CCLE	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0833
p.G259S	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0833
p.D274E	DO46542	OV	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.5647
p.R273W	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.7523
p.R273W	SIDM01680	Non-Cancerous	GDSC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.7523
p.R273W	ACH-000589	Lung Cancer	CCLE	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.7523
p.R273W	ACH-002364	Non-Cancerous	CCLE	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.7523
p.G259C	SIDM00814	Other Solid Cancers	GDSC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0833
p.G259C	ACH-001401	Adrenal Cancer	CCLE	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0833
p.G259C	SW13	adrenal gland	COSMIC	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0833
p.V316E	SIDM00951	T-Lymphoblastic Leukemia	GDSC	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.6582
p.V316E	ACH-002222	Leukemia	CCLE	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.6582
p.V316E	CTV-1	haematopoietic and lymphoid tissue	COSMIC	TRPGLGTMV	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.6582
p.E296K	ACH-000975	Lung Cancer	CCLE	DSGHDS	DEG_SCF_TRCP1_1	300:305	Mutation rewiring degron network	0.2222
p.P271S	ACH-001982	Metastasis	CCLE	GRAPLRDMF	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.5641

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USH1G

UniProt ID: Q495M9

Entrez ID: 124590

Protein name: Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USH1G in