DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
TRPGLGTMV
Uniprot ID:
Q495M9
Source protein:
Usher syndrome type-1G protein
Source gene:
USH1G
Class:
DEG_APCC_DBOX_1
Location:
308:316
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5646
ASA_SCORE:
61.3444
COIL:
0.6771
CONS_SCORE:
0.6755
DSS_SCORE:
0.3368
HELIX:
0.0506
FCONS_SCORE:
1.0472
RIG_SCORE:
0.7592
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L312M
TCGA-44-3398
LUAD
TCGA
TRPGLGTMV
DEG_APCC_DBOX_1
0.711
p.L312M
DO25030
LUAD
ICGC
TRPGLGTMV
DEG_APCC_DBOX_1
0.711
p.R318C
TCGA-AG-A01W
READ
TCGA
TRPGLGTMV
DEG_APCC_DBOX_1
0.2778
p.R318C
DO36382
READ
ICGC
TRPGLGTMV
DEG_APCC_DBOX_1
0.2778
p.R318H
TCGA-B5-A3FC
UCEC
TCGA
TRPGLGTMV
DEG_APCC_DBOX_1
0.2778
p.R318H
TCGA-DF-A2KN
UCEC
TCGA
TRPGLGTMV
DEG_APCC_DBOX_1
0.2778
p.R318H
DO223282
UCEC
ICGC
TRPGLGTMV
DEG_APCC_DBOX_1
0.2778
p.R318H
DO41871
UCEC
ICGC
TRPGLGTMV
DEG_APCC_DBOX_1
0.2778
p.V316A
TCGA-DU-6392
LGG
TCGA
TRPGLGTMV
DEG_APCC_DBOX_1
0.5825
p.V316A
DO22237
LGG
ICGC
TRPGLGTMV
DEG_APCC_DBOX_1
0.5825
p.M315T
TCGA-NC-A5HO
LUSC
TCGA
TRPGLGTMV
DEG_APCC_DBOX_1
0.7423
p.M315T
TCGA-VQ-A91E
STAD
TCGA
TRPGLGTMV
DEG_APCC_DBOX_1
0.7423
p.M315T
DO219197
LUSC
ICGC
TRPGLGTMV
DEG_APCC_DBOX_1
0.7423
p.M315T
DO51784
STAD
ICGC
TRPGLGTMV
DEG_APCC_DBOX_1
0.7423
p.P310H
TCGA-WS-AB45
COAD
TCGA
TRPGLGTMV
DEG_APCC_DBOX_1
0.6583
p.P310H
DO51734
COAD
ICGC
TRPGLGTMV
DEG_APCC_DBOX_1
0.6583
p.T308N
DO228390
LICA
ICGC
TRPGLGTMV
DEG_APCC_DBOX_1
0.5944
p.S298R
DO229006
LICA
ICGC
TRPGLGTMV
DEG_APCC_DBOX_1
0.0556
p.V316E
SIDM00951
T-Lymphoblastic Leukemia
GDSC
TRPGLGTMV
DEG_APCC_DBOX_1
0.6582
p.V316E
ACH-002222
Leukemia
CCLE
TRPGLGTMV
DEG_APCC_DBOX_1
0.6582
p.V316E
CTV-1
haematopoietic_and_lymphoid_tissue
COSMIC
TRPGLGTMV
DEG_APCC_DBOX_1
0.6582
Drug responses associated with USH1G mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TRPGLGTMV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q495M9
Usher syndrome type-1G protein
DEG_APCC_DBOX_1
308:316
TRPGLGTMV
APC,CDC20,FZR1
0.5646
More...