DegronMD

Uniprot ID: Q495M9

Source protein: Usher syndrome type-1G protein

Source gene: USH1G

Class: DEG_SCF_TRCP1_1

Location: 300:305

E3 ligase: BTRC

DEGRON score: 0.9169

ASA_SCORE: 74.35

COIL: 0.8307

CONS_SCORE: 0.5971

DSS_SCORE: 0.5277

HELIX: 0.124

FCONS_SCORE: 0.8903

RIG_SCORE: 0.6631

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G302D	TCGA-D7-A4YY	STAD	TCGA	DSGHDS	DEG_SCF_TRCP1_1	0.7198
p.G302D	DO47733	STAD	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.7198
p.D304V	TCGA-VQ-A8PP	STAD	TCGA	DSGHDS	DEG_SCF_TRCP1_1	0.6674
p.D304V	DO51774	STAD	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.6674
p.S295L	DO233203	GACA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.1944
p.A293D	DO229027	LICA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.1389
p.S298R	DO229006	LICA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.2778
p.E296K	ACH-000975	Lung Cancer	CCLE	DSGHDS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q495M9	Usher syndrome type-1G protein	DEG_SCF_TRCP1_1	300:305	DSGHDS	BTRC	0.9169	More...
Q7Z4K8	Tripartite motif-containing protein 46	DEG_SCF_TRCP1_1	633:638	DSGHDS	BTRC	0.809	More...
Q9NQ86	E3 ubiquitin-protein ligase TRIM36	DEG_SCF_TRCP1_1	615:620	DSGHDS	BTRC	0.8094	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SCF_TRCP1_1	1589:1594	DSGHDS	BTRC	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons