DegronMD - Q7Z4K8(TRIM46)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G635R	TCGA-A8-A07C	BRCA	TCGA	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation altering degron motif	0.7568
p.G635R	DO4713	BRCA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation altering degron motif	0.7568
p.A640V	TCGA-AP-A0LM	UCEC	TCGA	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.2778
p.A640V	DO43306	UCEC	ICGC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.2778
p.A640V	SIDM00151	Ovarian Carcinoma	GDSC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.2778
p.A640V	ACH-000966	Ovarian Cancer	CCLE	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.2778
p.A640V	IGROV-1	ovary	COSMIC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.2778
p.S648L	TCGA-AZ-4315	COAD	TCGA	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.0556
p.S648L	DO8842	COAD	ICGC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.0556
p.G635W	TCGA-BH-A18G	BRCA	TCGA	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation altering degron motif	0.7825
p.G635W	DO3686	BRCA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation altering degron motif	0.7825
p.D624N	TCGA-BK-A6W3	UCEC	TCGA	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.0833
p.D624N	DO50076	UCEC	ICGC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.0833
p.I626L	TCGA-CA-6718	COAD	TCGA	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.1389
p.I626L	DO7801	COAD	ICGC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.1389
p.P628L	TCGA-DA-A1IC	SKCM	TCGA	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.1944
p.P628L	DO37430	SKCM	ICGC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.1944
p.P628L	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.1944
p.P628L	ACH-000851	Lung Cancer	CCLE	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.1944
p.A643V	TCGA-EB-A5SE	SKCM	TCGA	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.1944
p.A643V	DO47295	SKCM	ICGC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.1944
p.A647V	TCGA-F5-6814	READ	TCGA	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.0833
p.A647V	TCGA-XK-AAIW	PRAD	TCGA	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.0833
p.A647V	DO51407	PRAD	ICGC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.0833
p.A647V	DO36556	READ	ICGC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.0833
p.P632L	TCGA-GS-A9TZ	DLBC	TCGA	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.3056
p.P632L	DO219918	DLBC	ICGC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.3056
p.W639C	DO44096	COAD	ICGC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.3056
p.G639S	DO233864	GACA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.3056
p.V645L	DO229045	LICA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.1389
p.R635K	DO222363	MELA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation altering degron motif	0.7237
p.S633F	DO222557	MELA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation altering degron motif	0.7982
p.E641K	SIDM01943	Colorectal Carcinoma	GDSC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.25
p.R629G	LoVo	large intestine	COSMIC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.2222
p.A627V	IGROV-1	ovary	COSMIC	DSGHDS	DEG_SCF_TRCP1_1	633:638	Mutation blocking phosphorylation signal	0.6111

Kaplan plot for TRIM46 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIM46

UniProt ID: Q7Z4K8

Entrez ID: 80128

Protein name: Tripartite motif-containing protein 46 (Gene Y protein) (GeneY) (Tripartite, fibronectin type-III and C-terminal SPRY motif protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIM46 in