DegronMD

Uniprot ID: Q7Z4K8

Source protein: Tripartite motif-containing protein 46

Source gene: TRIM46

Class: DEG_SCF_TRCP1_1

Location: 633:638

E3 ligase: BTRC

DEGRON score: 0.809

ASA_SCORE: 50.2667

COIL: 0.8138

CONS_SCORE: 0.6028

DSS_SCORE: 0.6543

HELIX: 0.114

FCONS_SCORE: 1.4937

RIG_SCORE: 0.5761

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G635R	TCGA-A8-A07C	BRCA	TCGA	DSGHDS	DEG_SCF_TRCP1_1	0.7568
p.G635R	DO4713	BRCA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.7568
p.A640V	TCGA-AP-A0LM	UCEC	TCGA	DSGHDS	DEG_SCF_TRCP1_1	0.2778
p.A640V	DO43306	UCEC	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.2778
p.A640V	SIDM00151	Ovarian Carcinoma	GDSC	DSGHDS	DEG_SCF_TRCP1_1	0.2778
p.A640V	ACH-000966	Ovarian Cancer	CCLE	DSGHDS	DEG_SCF_TRCP1_1	0.2778
p.A640V	IGROV-1	ovary	COSMIC	DSGHDS	DEG_SCF_TRCP1_1	0.2778
p.S648L	TCGA-AZ-4315	COAD	TCGA	DSGHDS	DEG_SCF_TRCP1_1	0.0556
p.S648L	DO8842	COAD	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.0556
p.G635W	TCGA-BH-A18G	BRCA	TCGA	DSGHDS	DEG_SCF_TRCP1_1	0.7825
p.G635W	DO3686	BRCA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.7825
p.D624N	TCGA-BK-A6W3	UCEC	TCGA	DSGHDS	DEG_SCF_TRCP1_1	0.0833
p.D624N	DO50076	UCEC	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.0833
p.I626L	TCGA-CA-6718	COAD	TCGA	DSGHDS	DEG_SCF_TRCP1_1	0.1389
p.I626L	DO7801	COAD	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.1389
p.P628L	TCGA-DA-A1IC	SKCM	TCGA	DSGHDS	DEG_SCF_TRCP1_1	0.1944
p.P628L	DO37430	SKCM	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.1944
p.P628L	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	DSGHDS	DEG_SCF_TRCP1_1	0.1944
p.P628L	ACH-000851	Lung Cancer	CCLE	DSGHDS	DEG_SCF_TRCP1_1	0.1944
p.A643V	TCGA-EB-A5SE	SKCM	TCGA	DSGHDS	DEG_SCF_TRCP1_1	0.1944
p.A643V	DO47295	SKCM	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.1944
p.A647V	TCGA-F5-6814	READ	TCGA	DSGHDS	DEG_SCF_TRCP1_1	0.0833
p.A647V	TCGA-XK-AAIW	PRAD	TCGA	DSGHDS	DEG_SCF_TRCP1_1	0.0833
p.A647V	DO51407	PRAD	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.0833
p.A647V	DO36556	READ	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.0833
p.P632L	TCGA-GS-A9TZ	DLBC	TCGA	DSGHDS	DEG_SCF_TRCP1_1	0.3056
p.P632L	DO219918	DLBC	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.3056
p.W639C	DO44096	COAD	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.3056
p.G639S	DO233864	GACA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.3056
p.V645L	DO229045	LICA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.1389
p.R635K	DO222363	MELA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.7237
p.S633F	DO222557	MELA	ICGC	DSGHDS	DEG_SCF_TRCP1_1	0.7982
p.E641K	SIDM01943	Colorectal Carcinoma	GDSC	DSGHDS	DEG_SCF_TRCP1_1	0.25
p.R629G	LoVo	large_intestine	COSMIC	DSGHDS	DEG_SCF_TRCP1_1	0.2222
p.A627V	IGROV-1	ovary	COSMIC	DSGHDS	DEG_SCF_TRCP1_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q495M9	Usher syndrome type-1G protein	DEG_SCF_TRCP1_1	300:305	DSGHDS	BTRC	0.9169	More...
Q7Z4K8	Tripartite motif-containing protein 46	DEG_SCF_TRCP1_1	633:638	DSGHDS	BTRC	0.809	More...
Q9NQ86	E3 ubiquitin-protein ligase TRIM36	DEG_SCF_TRCP1_1	615:620	DSGHDS	BTRC	0.8094	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SCF_TRCP1_1	1589:1594	DSGHDS	BTRC	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGHDS

Degron related mutations and impact score

Drug responses associated with TRIM46 mutations

All proteins holding degron of DSGHDS