DegronMD

Uniprot ID: Q9NQ86

Source protein: E3 ubiquitin-protein ligase TRIM36

Source gene: TRIM36

Class: DEG_SCF_TRCP1_1

Location: 615:620

E3 ligase: BTRC

DEGRON score: 0.8094

ASA_SCORE: 39.1833

COIL: 0.8062

CONS_SCORE: 0.4668

DSS_SCORE: 0.6057

HELIX: 0.0777

FCONS_SCORE: 1.3915

RIG_SCORE: 0.5765

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V608I	TCGA-HC-7233	PRAD	TCGA	DSGHDS	DEG_SCF_TRCP1_1	0.1389
p.E613K	TCGA-XF-A9T0	BLCA	TCGA	DSGHDS	DEG_SCF_TRCP1_1	0.2778
p.R605Q	SIDM00976	Melanoma	GDSC	DSGHDS	DEG_SCF_TRCP1_1	0.0556
p.R605Q	ACH-002205	Skin Cancer	CCLE	DSGHDS	DEG_SCF_TRCP1_1	0.0556
p.R605Q	WM1552C	skin	COSMIC	DSGHDS	DEG_SCF_TRCP1_1	0.0556
p.G621R	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	DSGHDS	DEG_SCF_TRCP1_1	0.3056
p.G621R	ACH-000851	Lung Cancer	CCLE	DSGHDS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q495M9	Usher syndrome type-1G protein	DEG_SCF_TRCP1_1	300:305	DSGHDS	BTRC	0.9169	More...
Q7Z4K8	Tripartite motif-containing protein 46	DEG_SCF_TRCP1_1	633:638	DSGHDS	BTRC	0.809	More...
Q9NQ86	E3 ubiquitin-protein ligase TRIM36	DEG_SCF_TRCP1_1	615:620	DSGHDS	BTRC	0.8094	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SCF_TRCP1_1	1589:1594	DSGHDS	BTRC	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons