DegronMD - Q9NQ86(TRIM36)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V429I	TCGA-09-2049	OV	TCGA	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.1389
p.V429F	TCGA-39-5029	LUSC	TCGA	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.1389
p.Q426H	TCGA-A5-A0G2	UCEC	TCGA	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.2222
p.N97T	TCGA-AJ-A3EL	UCEC	TCGA	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.0833
p.N97T	DO41542	UCEC	ICGC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.0833
p.V419A	TCGA-BQ-5885	KIRP	TCGA	SSGIDVPEI	DEG_COP1_1	414:422	Mutation altering degron motif	0.6936
p.F113Y	TCGA-D3-A8GI	SKCM	TCGA	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.2778
p.F113Y	DO50284	SKCM	ICGC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.2778
p.G100V	TCGA-D6-A74Q	HNSC	TCGA	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.1667
p.P114S	TCGA-DA-A1IC	SKCM	TCGA	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.25
p.E421D	TCGA-E6-A1LX	UCEC	TCGA	SSGIDVPEI	DEG_COP1_1	414:422	Mutation altering degron motif	0.5647
p.S411F	TCGA-FS-A1Z3	SKCM	TCGA	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.25
p.V608I	TCGA-HC-7233	PRAD	TCGA	DSGHDS	DEG_SCF_TRCP1_1	615:620	Mutation rewiring degron network	0.1389
p.T404A	TCGA-KU-A6H7	HNSC	TCGA	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.0556
p.E613K	TCGA-XF-A9T0	BLCA	TCGA	DSGHDS	DEG_SCF_TRCP1_1	615:620	Mutation rewiring degron network	0.2778
p.R424P	DO7828	COAD	ICGC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.2778
p.K104Q	DO222762	COCA	ICGC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.2778
p.R103H	DO233767	GACA	ICGC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.25
p.R103C	DO233885	GACA	ICGC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.25
p.I414T	DO13863	GBM	ICGC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation altering degron motif	0.7078
p.P427Q	DO229026	LICA	ICGC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.1944
p.H419N	DO229006	LICA	ICGC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation altering degron motif	0.7423
p.T107N	DO229009	LICA	ICGC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation altering degron motif	0.8166
p.A97S	DO26414	LUAD	ICGC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.0833
p.D406N	DO26384	LUAD	ICGC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.1111
p.F420V	DO23627	LUAD	ICGC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation altering degron motif	0.7068
p.I409T	DO228865	MALY	ICGC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.1944
p.E103K	DO222818	MELA	ICGC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.25
p.R424C	DO220239	SARC	ICGC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.2778
p.R424C	DO37444	SKCM	ICGC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.2778
p.R115Q	DO37819	SKCM	ICGC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.2222
p.L112I	DO37462	SKCM	ICGC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.3056
p.P102S	DO37430	SKCM	ICGC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation substituting flanking lysine	0.3333
p.E426K	DO47453	SKCM	ICGC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.2222
p.F420Y	DO219468	SKCM	ICGC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation altering degron motif	0.7528
p.D411Y	DO41572	UCEC	ICGC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.25
p.G114D	DO43795	UCEC	ICGC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.25
p.V419M	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation altering degron motif	0.7208
p.V419M	SIDM00519	Mesothelioma	GDSC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation altering degron motif	0.7208
p.V419M	SIDM01591	Breast Carcinoma	GDSC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation altering degron motif	0.7208
p.V419M	SIDM01590	Breast Carcinoma	GDSC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation altering degron motif	0.7208
p.L106F	SIDM00534	Colorectal Carcinoma	GDSC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation altering degron motif	0.6981
p.L106F	ACH-000986	Colon/Colorectal Cancer	CCLE	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation altering degron motif	0.6981
p.L106F	HT-115	large intestine	COSMIC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation altering degron motif	0.6981
p.V112A	SIDM00381	Cervical Carcinoma	GDSC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.3056
p.V112A	ACH-002020	Cervical Cancer	CCLE	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.3056
p.V112A	SKG-IIIa	cervix	COSMIC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.3056
p.R605Q	SIDM00976	Melanoma	GDSC	DSGHDS	DEG_SCF_TRCP1_1	615:620	Mutation rewiring degron network	0.0556
p.R605Q	ACH-002205	Skin Cancer	CCLE	DSGHDS	DEG_SCF_TRCP1_1	615:620	Mutation rewiring degron network	0.0556
p.R605Q	WM1552C	skin	COSMIC	DSGHDS	DEG_SCF_TRCP1_1	615:620	Mutation rewiring degron network	0.0556
p.E405D	SIDM01567	Hodgkin's Lymphoma	GDSC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.0833
p.E405D	ACH-000069	Lymphoma	CCLE	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.0833
p.G621R	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	DSGHDS	DEG_SCF_TRCP1_1	615:620	Mutation rewiring degron network	0.3056
p.G621R	ACH-000851	Lung Cancer	CCLE	DSGHDS	DEG_SCF_TRCP1_1	615:620	Mutation rewiring degron network	0.3056
p.P99S	ACH-000215	Brain Cancer	CCLE	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.1389
p.I409N	SLVL	haematopoietic and lymphoid tissue	COSMIC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.1944
p.W425L	HC-1	haematopoietic and lymphoid tissue	COSMIC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.25
p.N118K	MKN45	stomach	COSMIC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.1389
p.V119L	NCI-H209	lung	COSMIC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.1111
p.K430T	MS751	cervix	COSMIC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation rewiring degron network	0.1111
p.W421L	TYK-nu	ovary	COSMIC	SSGIDVPEI	DEG_COP1_1	414:422	Mutation altering degron motif	0.7015
p.V100A	SKG-IIIa	cervix	COSMIC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.1667
p.Q118H	NCI-H209	lung	COSMIC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation rewiring degron network	0.1389
p.K107T	MFE-319	endometrium	COSMIC	LTPRTT	DEG_SCF_FBW7_1	106:111	Mutation altering degron motif	0.7306

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIM36

UniProt ID: Q9NQ86

Entrez ID: 55521

Protein name: E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIM36 in