DegronMD

Uniprot ID: Q9NQ86

Source protein: E3 ubiquitin-protein ligase TRIM36

Source gene: TRIM36

Class: DEG_SCF_FBW7_1

Location: 106:111

E3 ligase: FBXW7

DEGRON score: 0.9607

ASA_SCORE: 88.6333

COIL: 0.7998

CONS_SCORE: 0.4099

DSS_SCORE: 0.4196

HELIX: 0.0223

FCONS_SCORE: 0.8633

RIG_SCORE: 0.7322

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N97T	TCGA-AJ-A3EL	UCEC	TCGA	LTPRTT	DEG_SCF_FBW7_1	0.0833
p.N97T	DO41542	UCEC	ICGC	LTPRTT	DEG_SCF_FBW7_1	0.0833
p.F113Y	TCGA-D3-A8GI	SKCM	TCGA	LTPRTT	DEG_SCF_FBW7_1	0.2778
p.F113Y	DO50284	SKCM	ICGC	LTPRTT	DEG_SCF_FBW7_1	0.2778
p.G100V	TCGA-D6-A74Q	HNSC	TCGA	LTPRTT	DEG_SCF_FBW7_1	0.1667
p.P114S	TCGA-DA-A1IC	SKCM	TCGA	LTPRTT	DEG_SCF_FBW7_1	0.25
p.K104Q	DO222762	COCA	ICGC	LTPRTT	DEG_SCF_FBW7_1	0.2778
p.R103H	DO233767	GACA	ICGC	LTPRTT	DEG_SCF_FBW7_1	0.25
p.R103C	DO233885	GACA	ICGC	LTPRTT	DEG_SCF_FBW7_1	0.25
p.T107N	DO229009	LICA	ICGC	LTPRTT	DEG_SCF_FBW7_1	0.8166
p.A97S	DO26414	LUAD	ICGC	LTPRTT	DEG_SCF_FBW7_1	0.0833
p.E103K	DO222818	MELA	ICGC	LTPRTT	DEG_SCF_FBW7_1	0.25
p.R115Q	DO37819	SKCM	ICGC	LTPRTT	DEG_SCF_FBW7_1	0.2222
p.L112I	DO37462	SKCM	ICGC	LTPRTT	DEG_SCF_FBW7_1	0.3056
p.P102S	DO37430	SKCM	ICGC	LTPRTT	DEG_SCF_FBW7_1	0.3333
p.G114D	DO43795	UCEC	ICGC	LTPRTT	DEG_SCF_FBW7_1	0.25
p.L106F	SIDM00534	Colorectal Carcinoma	GDSC	LTPRTT	DEG_SCF_FBW7_1	0.6981
p.L106F	ACH-000986	Colon/Colorectal Cancer	CCLE	LTPRTT	DEG_SCF_FBW7_1	0.6981
p.L106F	HT-115	large_intestine	COSMIC	LTPRTT	DEG_SCF_FBW7_1	0.6981
p.V112A	SIDM00381	Cervical Carcinoma	GDSC	LTPRTT	DEG_SCF_FBW7_1	0.3056
p.V112A	ACH-002020	Cervical Cancer	CCLE	LTPRTT	DEG_SCF_FBW7_1	0.3056
p.V112A	SKG-IIIa	cervix	COSMIC	LTPRTT	DEG_SCF_FBW7_1	0.3056
p.P99S	ACH-000215	Brain Cancer	CCLE	LTPRTT	DEG_SCF_FBW7_1	0.1389
p.N118K	MKN45	stomach	COSMIC	LTPRTT	DEG_SCF_FBW7_1	0.1389
p.V119L	NCI-H209	lung	COSMIC	LTPRTT	DEG_SCF_FBW7_1	0.1111
p.V100A	SKG-IIIa	cervix	COSMIC	LTPRTT	DEG_SCF_FBW7_1	0.1667
p.Q118H	NCI-H209	lung	COSMIC	LTPRTT	DEG_SCF_FBW7_1	0.1389
p.K107T	MFE-319	endometrium	COSMIC	LTPRTT	DEG_SCF_FBW7_1	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ86	E3 ubiquitin-protein ligase TRIM36	DEG_SCF_FBW7_1	106:111	LTPRTT	FBXW7	0.9607	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPRTT

Degron related mutations and impact score

Drug responses associated with TRIM36 mutations

All proteins holding degron of LTPRTT