DegronMD

Uniprot ID: Q9NQ86

Source protein: E3 ubiquitin-protein ligase TRIM36

Source gene: TRIM36

Class: DEG_COP1_1

Location: 414:422

E3 ligase: COP1

DEGRON score: 0.9448

ASA_SCORE: 62.0444

COIL: 0.7447

CONS_SCORE: 0.3126

DSS_SCORE: 0.291

HELIX: 0.0526

FCONS_SCORE: 0.7831

RIG_SCORE: 0.7717

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V429I	TCGA-09-2049	OV	TCGA	SSGIDVPEI	DEG_COP1_1	0.1389
p.V429F	TCGA-39-5029	LUSC	TCGA	SSGIDVPEI	DEG_COP1_1	0.1389
p.Q426H	TCGA-A5-A0G2	UCEC	TCGA	SSGIDVPEI	DEG_COP1_1	0.2222
p.V419A	TCGA-BQ-5885	KIRP	TCGA	SSGIDVPEI	DEG_COP1_1	0.6936
p.E421D	TCGA-E6-A1LX	UCEC	TCGA	SSGIDVPEI	DEG_COP1_1	0.5647
p.S411F	TCGA-FS-A1Z3	SKCM	TCGA	SSGIDVPEI	DEG_COP1_1	0.25
p.T404A	TCGA-KU-A6H7	HNSC	TCGA	SSGIDVPEI	DEG_COP1_1	0.0556
p.R424P	DO7828	COAD	ICGC	SSGIDVPEI	DEG_COP1_1	0.2778
p.I414T	DO13863	GBM	ICGC	SSGIDVPEI	DEG_COP1_1	0.7078
p.P427Q	DO229026	LICA	ICGC	SSGIDVPEI	DEG_COP1_1	0.1944
p.H419N	DO229006	LICA	ICGC	SSGIDVPEI	DEG_COP1_1	0.7423
p.D406N	DO26384	LUAD	ICGC	SSGIDVPEI	DEG_COP1_1	0.1111
p.F420V	DO23627	LUAD	ICGC	SSGIDVPEI	DEG_COP1_1	0.7068
p.I409T	DO228865	MALY	ICGC	SSGIDVPEI	DEG_COP1_1	0.1944
p.R424C	DO220239	SARC	ICGC	SSGIDVPEI	DEG_COP1_1	0.2778
p.R424C	DO37444	SKCM	ICGC	SSGIDVPEI	DEG_COP1_1	0.2778
p.E426K	DO47453	SKCM	ICGC	SSGIDVPEI	DEG_COP1_1	0.2222
p.F420Y	DO219468	SKCM	ICGC	SSGIDVPEI	DEG_COP1_1	0.7528
p.D411Y	DO41572	UCEC	ICGC	SSGIDVPEI	DEG_COP1_1	0.25
p.V419M	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	SSGIDVPEI	DEG_COP1_1	0.7208
p.V419M	SIDM00519	Mesothelioma	GDSC	SSGIDVPEI	DEG_COP1_1	0.7208
p.V419M	SIDM01591	Breast Carcinoma	GDSC	SSGIDVPEI	DEG_COP1_1	0.7208
p.V419M	SIDM01590	Breast Carcinoma	GDSC	SSGIDVPEI	DEG_COP1_1	0.7208
p.E405D	SIDM01567	Hodgkin's Lymphoma	GDSC	SSGIDVPEI	DEG_COP1_1	0.0833
p.E405D	ACH-000069	Lymphoma	CCLE	SSGIDVPEI	DEG_COP1_1	0.0833
p.I409N	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	SSGIDVPEI	DEG_COP1_1	0.1944
p.W425L	HC-1	haematopoietic_and_lymphoid_tissue	COSMIC	SSGIDVPEI	DEG_COP1_1	0.25
p.K430T	MS751	cervix	COSMIC	SSGIDVPEI	DEG_COP1_1	0.1111
p.W421L	TYK-nu	ovary	COSMIC	SSGIDVPEI	DEG_COP1_1	0.7015

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ86	E3 ubiquitin-protein ligase TRIM36	DEG_COP1_1	414:422	SSGIDVPEI	COP1	0.9448	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSGIDVPEI

Degron related mutations and impact score

Drug responses associated with TRIM36 mutations

All proteins holding degron of SSGIDVPEI