DegronMD

Uniprot ID: Q495M9

Source protein: Usher syndrome type-1G protein

Source gene: USH1G

Class: DEG_APCC_DBOX_1

Location: 268:276

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5531

ASA_SCORE: 60.0111

COIL: 0.5129

CONS_SCORE: 0.6588

DSS_SCORE: 0.4059

HELIX: 0.3783

FCONS_SCORE: 1.0602

RIG_SCORE: 0.7948

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A286V	TCGA-06-0152	GBM	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	0.0556
p.A286V	DO11238	GBM	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	0.0556
p.F276L	TCGA-AA-3984	COAD	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	0.587
p.F276L	DO9002	COAD	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	0.587
p.E280K	TCGA-B5-A0JY	UCEC	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	0.2222
p.E280K	DO43041	UCEC	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	0.2222
p.A262T	TCGA-B5-A11L	UCEC	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	0.1667
p.A262T	DO42961	UCEC	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	0.1667
p.R273L	TCGA-BF-A1Q0	SKCM	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	0.7316
p.R273L	DO47374	SKCM	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	0.7316
p.R285S	TCGA-DF-A2KN	UCEC	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	0.0833
p.R285S	DO223282	UCEC	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	0.0833
p.N263I	TCGA-EE-A2GR	SKCM	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	0.1944
p.N263I	DO37996	SKCM	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	0.1944
p.L277F	TCGA-EE-A2M8	SKCM	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	0.3056
p.L277F	DO38075	SKCM	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	0.3056
p.T260A	TCGA-FS-A1ZT	SKCM	TCGA	GRAPLRDMF	DEG_APCC_DBOX_1	0.1111
p.T260A	DO37468	SKCM	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	0.1111
p.Y261N	DO228848	LICA	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	0.1389
p.W267R	DO52664	MALY	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	0.3056
p.G259S	DO222837	MELA	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	0.0833
p.G259S	SIDM00422	Hodgkin's Lymphoma	GDSC	GRAPLRDMF	DEG_APCC_DBOX_1	0.0833
p.G259S	ACH-001203	Lymphoma	CCLE	GRAPLRDMF	DEG_APCC_DBOX_1	0.0833
p.G259S	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	GRAPLRDMF	DEG_APCC_DBOX_1	0.0833
p.D274E	DO46542	OV	ICGC	GRAPLRDMF	DEG_APCC_DBOX_1	0.5647
p.R273W	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	GRAPLRDMF	DEG_APCC_DBOX_1	0.7523
p.R273W	SIDM01680	Non-Cancerous	GDSC	GRAPLRDMF	DEG_APCC_DBOX_1	0.7523
p.R273W	ACH-000589	Lung Cancer	CCLE	GRAPLRDMF	DEG_APCC_DBOX_1	0.7523
p.R273W	ACH-002364	Non-Cancerous	CCLE	GRAPLRDMF	DEG_APCC_DBOX_1	0.7523
p.G259C	SIDM00814	Other Solid Cancers	GDSC	GRAPLRDMF	DEG_APCC_DBOX_1	0.0833
p.G259C	ACH-001401	Adrenal Cancer	CCLE	GRAPLRDMF	DEG_APCC_DBOX_1	0.0833
p.G259C	SW13	adrenal_gland	COSMIC	GRAPLRDMF	DEG_APCC_DBOX_1	0.0833
p.P271S	ACH-001982	Metastasis	CCLE	GRAPLRDMF	DEG_APCC_DBOX_1	0.5641

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRAPLRDMF

Degron related mutations and impact score

Drug responses associated with USH1G mutations

All proteins holding degron of GRAPLRDMF

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q495M9	Usher syndrome type-1G protein	DEG_APCC_DBOX_1	268:276	GRAPLRDMF	APC,CDC20,FZR1	0.5531	More...