DegronMD

Uniprot ID: Q6UVJ0

Source protein: Spindle assembly abnormal protein 6 homolog

Source gene: SASS6

Class: DEG_SPOP_SBC_1

Location: 498:502

E3 ligase: SPOP

DEGRON score: 0.9472

ASA_SCORE: 83.86

COIL: 0.9208

CONS_SCORE: 0.2605

DSS_SCORE: 0.6433

HELIX: 0.031

FCONS_SCORE: 0.8584

RIG_SCORE: 0.6126

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T494A	TCGA-85-A512	LUSC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.2222
p.P492H	TCGA-BP-5174	KIRC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1667
p.T495P	TCGA-EO-A3AV	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.6944
p.L490F	TCGA-FS-A1ZW	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1111
p.D488V	TCGA-HU-A4G8	STAD	TCGA	AHSSS	DEG_SPOP_SBC_1	0.0556
p.D488V	DO47819	STAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.0556
p.H499P	DO228557	GACA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.6583

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15015	Zinc finger protein 646	DEG_SPOP_SBC_1	903:907	AHSSS	SPOP	0.9691	More...
O60269	G protein-regulated inducer of neurite outgrowth 2	DEG_SPOP_SBC_1	206:210	AHSSS	SPOP	0.855	More...
O95425	Supervillin	DEG_SPOP_SBC_1	249:253	AHSSS	SPOP	0.9277	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	464:468	AHSSS	SPOP	0.8527	More...
Q13416	Origin recognition complex subunit 2	DEG_SPOP_SBC_1	246:250	AHSSS	SPOP	0.8711	More...
Q13586	Stromal interaction molecule 1	DEG_SPOP_SBC_1	397:401	AHSSS	SPOP	0.9518	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_SPOP_SBC_1	498:502	AHSSS	SPOP	0.9472	More...
Q05952	Nuclear transition protein 2	DEG_SPOP_SBC_1	62:66	AHSSS	SPOP	0.9869	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	211:215	AHSSS	SPOP	0.5387	More...
Q8WYN3	Cysteine/serine-rich nuclear protein 3	DEG_SPOP_SBC_1	297:301	AHSSS	SPOP	0.8601	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SPOP_SBC_1	1445:1449	AHSSS	SPOP	0.9988	More...
A6NMT0	Homeobox protein DBX1	DEG_SPOP_SBC_1	314:318	AHSSS	SPOP	0.9343	More...
C9J798	Ras GTPase-activating protein 4B	DEG_SPOP_SBC_1	782:786	AHSSS	SPOP	0.6288	More...
Q2WGJ9	Fer-1-like protein 6	DEG_SPOP_SBC_1	1123:1127	AHSSS	SPOP	0.7335	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	422:426	AHSSS	SPOP	0.9446	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	694:698	AHSSS	SPOP	0.9817	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	76:80	AHSSS	SPOP	0.9484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons