DegronMD

Uniprot ID: Q2WGJ9

Source protein: Fer-1-like protein 6

Source gene: FER1L6

Class: DEG_SPOP_SBC_1

Location: 1123:1127

E3 ligase: SPOP

DEGRON score: 0.7335

ASA_SCORE: 70.74

COIL: 0.7818

CONS_SCORE: 0.2605

DSS_SCORE: 0.7541

HELIX: 0.1174

FCONS_SCORE: 0.8914

RIG_SCORE: 0.5096

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1116K	TCGA-17-Z010	LUAD	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1389
p.S1125I	TCGA-17-Z053	LUAD	TCGA	AHSSS	DEG_SPOP_SBC_1	0.7341
p.S1127F	TCGA-60-2714	LUSC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.7982
p.S1127F	DO26530	LUSC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.7982
p.P1130T	TCGA-C8-A26Y	BRCA	TCGA	AHSSS	DEG_SPOP_SBC_1	0.25
p.P1130T	DO1273	BRCA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.25
p.H1134Y	TCGA-D3-A3MV	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1389
p.H1134Y	TCGA-GN-A269	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1389
p.H1134Y	DO37727	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1389
p.H1134Y	DO37483	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1389
p.I1135V	TCGA-DI-A1BU	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1111
p.I1135V	DO42023	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1111
p.A1117S	TCGA-DX-A6YV	SARC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1667
p.A1117S	DO220011	SARC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1667
p.S1114L	TCGA-EE-A2MM	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	0.0833
p.S1114L	DO52481	COCA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.0833
p.S1114L	DO234158	ESAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.0833
p.S1114L	DO222678	MELA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.0833
p.S1114L	DO37770	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	0.0833
p.D1133H	TCGA-ER-A198	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1667
p.D1133H	DO47563	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1667
p.S1126P	TCGA-W3-AA1R	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	0.6752
p.S1126P	DO51275	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	0.6752
p.P1130S	TCGA-WE-AAA0	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	0.25
p.P1130S	DO51294	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	0.25
p.T1118P	TCGA-XF-A9T3	BLCA	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1944
p.T1118P	DO51922	BLCA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1944
p.P1130L	DO223555	CLLE	ICGC	AHSSS	DEG_SPOP_SBC_1	0.25
p.D1113N	DO222843	MELA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.0556
p.P1131L	DO229459	SKCA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.2222
p.D1129N	SIDM01228	Melanoma	GDSC	AHSSS	DEG_SPOP_SBC_1	0.2778
p.D1129N	ACH-001024	Skin Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	0.2778
p.D1129N	CHL-1	skin	COSMIC	AHSSS	DEG_SPOP_SBC_1	0.2778
p.D1133V	ACH-000593	Bladder Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	0.1667
p.S1121F	NCI-H630	large_intestine	COSMIC	AHSSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15015	Zinc finger protein 646	DEG_SPOP_SBC_1	903:907	AHSSS	SPOP	0.9691	More...
O60269	G protein-regulated inducer of neurite outgrowth 2	DEG_SPOP_SBC_1	206:210	AHSSS	SPOP	0.855	More...
O95425	Supervillin	DEG_SPOP_SBC_1	249:253	AHSSS	SPOP	0.9277	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	464:468	AHSSS	SPOP	0.8527	More...
Q13416	Origin recognition complex subunit 2	DEG_SPOP_SBC_1	246:250	AHSSS	SPOP	0.8711	More...
Q13586	Stromal interaction molecule 1	DEG_SPOP_SBC_1	397:401	AHSSS	SPOP	0.9518	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_SPOP_SBC_1	498:502	AHSSS	SPOP	0.9472	More...
Q05952	Nuclear transition protein 2	DEG_SPOP_SBC_1	62:66	AHSSS	SPOP	0.9869	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	211:215	AHSSS	SPOP	0.5387	More...
Q8WYN3	Cysteine/serine-rich nuclear protein 3	DEG_SPOP_SBC_1	297:301	AHSSS	SPOP	0.8601	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SPOP_SBC_1	1445:1449	AHSSS	SPOP	0.9988	More...
A6NMT0	Homeobox protein DBX1	DEG_SPOP_SBC_1	314:318	AHSSS	SPOP	0.9343	More...
C9J798	Ras GTPase-activating protein 4B	DEG_SPOP_SBC_1	782:786	AHSSS	SPOP	0.6288	More...
Q2WGJ9	Fer-1-like protein 6	DEG_SPOP_SBC_1	1123:1127	AHSSS	SPOP	0.7335	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	422:426	AHSSS	SPOP	0.9446	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	694:698	AHSSS	SPOP	0.9817	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	76:80	AHSSS	SPOP	0.9484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AHSSS

Degron related mutations and impact score

Drug responses associated with FER1L6 mutations

All proteins holding degron of AHSSS