DegronMD - Q13416(ORC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P117S	TCGA-A5-A0G2	UCEC	TCGA	LAKTPQKS	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.6752
p.P117S	DO41235	UCEC	ICGC	LAKTPQKS	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.6752
p.L253S	TCGA-CD-A4MG	STAD	TCGA	AHSSS	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.25
p.L253S	DO48009	STAD	ICGC	AHSSS	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.25
p.E245K	TCGA-D3-A5GN	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.3056
p.E245K	DO47317	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.3056
p.K119N	TCGA-EO-A3B0	UCEC	TCGA	LAKTPQKS	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.5806
p.K119N	DO219773	UCEC	ICGC	LAKTPQKS	DEG_SCF_FBW7_1	113:120	Mutation altering degron motif	0.5806
p.H247Y	TCGA-G4-6317	COAD	TCGA	AHSSS	DEG_SPOP_SBC_1	246:250	Mutation altering degron motif	0.6118
p.H247Y	DO10100	COAD	ICGC	AHSSS	DEG_SPOP_SBC_1	246:250	Mutation altering degron motif	0.6118
p.S111L	DO48386	BLCA	ICGC	LAKTPQKS	DEG_SCF_FBW7_1	113:120	Mutation blocking phosphorylation signal	0.7222
p.R257S	DO231962	LICA	ICGC	AHSSS	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.1389
p.S103Y	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAKTPQKS	DEG_SCF_FBW7_1	113:120	Mutation blocking phosphorylation signal	0.5
p.S103Y	JSC-1	haematopoietic and lymphoid tissue	COSMIC	LAKTPQKS	DEG_SCF_FBW7_1	113:120	Mutation blocking phosphorylation signal	0.5

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons