DegronMD

Uniprot ID: Q13416

Source protein: Origin recognition complex subunit 2

Source gene: ORC2

Class: DEG_SCF_FBW7_1

Location: 113:120

E3 ligase: FBXW7

DEGRON score: 0.8481

ASA_SCORE: 101.4125

COIL: 0.7153

CONS_SCORE: 0.4052

DSS_SCORE: 0.4578

HELIX: 0.2628

FCONS_SCORE: 0.9441

RIG_SCORE: 0.7108

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P117S	TCGA-A5-A0G2	UCEC	TCGA	LAKTPQKS	DEG_SCF_FBW7_1	0.6752
p.P117S	DO41235	UCEC	ICGC	LAKTPQKS	DEG_SCF_FBW7_1	0.6752
p.K119N	TCGA-EO-A3B0	UCEC	TCGA	LAKTPQKS	DEG_SCF_FBW7_1	0.5806
p.K119N	DO219773	UCEC	ICGC	LAKTPQKS	DEG_SCF_FBW7_1	0.5806
p.S111L	DO48386	BLCA	ICGC	LAKTPQKS	DEG_SCF_FBW7_1	0.7222
p.S103Y	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAKTPQKS	DEG_SCF_FBW7_1	0.5
p.S103Y	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	LAKTPQKS	DEG_SCF_FBW7_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13416	Origin recognition complex subunit 2	DEG_SCF_FBW7_1	113:120	LAKTPQKS	FBXW7	0.8481	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons