DegronMD

Uniprot ID: P51825

Source protein: AF4/FMR2 family member 1

Source gene: AFF1

Class: DEG_SPOP_SBC_1

Location: 464:468

E3 ligase: SPOP

DEGRON score: 0.8527

ASA_SCORE: 89.52

COIL: 0.868

CONS_SCORE: 0.5363

DSS_SCORE: 0.8043

HELIX: 0.1258

FCONS_SCORE: 1.2065

RIG_SCORE: 0.4968

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P465S	TCGA-AN-A0XN	BRCA	TCGA	AHSSS	DEG_SPOP_SBC_1	0.6752
p.S474N	TCGA-AP-A1DK	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1667
p.P458A	TCGA-CD-A4MG	STAD	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1667
p.S470L	TCGA-D3-A1QA	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	0.2778
p.H472R	TCGA-VR-A8EW	ESCA	TCGA	AHSSS	DEG_SPOP_SBC_1	0.2222
p.R466S	DO44096	COAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.7427
p.K469T	DO8264	COAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15015	Zinc finger protein 646	DEG_SPOP_SBC_1	903:907	AHSSS	SPOP	0.9691	More...
O60269	G protein-regulated inducer of neurite outgrowth 2	DEG_SPOP_SBC_1	206:210	AHSSS	SPOP	0.855	More...
O95425	Supervillin	DEG_SPOP_SBC_1	249:253	AHSSS	SPOP	0.9277	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	464:468	AHSSS	SPOP	0.8527	More...
Q13416	Origin recognition complex subunit 2	DEG_SPOP_SBC_1	246:250	AHSSS	SPOP	0.8711	More...
Q13586	Stromal interaction molecule 1	DEG_SPOP_SBC_1	397:401	AHSSS	SPOP	0.9518	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_SPOP_SBC_1	498:502	AHSSS	SPOP	0.9472	More...
Q05952	Nuclear transition protein 2	DEG_SPOP_SBC_1	62:66	AHSSS	SPOP	0.9869	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	211:215	AHSSS	SPOP	0.5387	More...
Q8WYN3	Cysteine/serine-rich nuclear protein 3	DEG_SPOP_SBC_1	297:301	AHSSS	SPOP	0.8601	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SPOP_SBC_1	1445:1449	AHSSS	SPOP	0.9988	More...
A6NMT0	Homeobox protein DBX1	DEG_SPOP_SBC_1	314:318	AHSSS	SPOP	0.9343	More...
C9J798	Ras GTPase-activating protein 4B	DEG_SPOP_SBC_1	782:786	AHSSS	SPOP	0.6288	More...
Q2WGJ9	Fer-1-like protein 6	DEG_SPOP_SBC_1	1123:1127	AHSSS	SPOP	0.7335	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	422:426	AHSSS	SPOP	0.9446	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	694:698	AHSSS	SPOP	0.9817	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	76:80	AHSSS	SPOP	0.9484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons