DegronMD - Q2WGJ9(FER1L6)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1116K	TCGA-17-Z010	LUAD	TCGA	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1389
p.S1125I	TCGA-17-Z053	LUAD	TCGA	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation altering degron motif	0.7341
p.A1097S	TCGA-44-3918	LUAD	TCGA	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation altering degron motif	0.6477
p.A1097S	DO23732	LUAD	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation altering degron motif	0.6477
p.S1127F	TCGA-60-2714	LUSC	TCGA	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation altering degron motif	0.7982
p.S1127F	DO26530	LUSC	ICGC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation altering degron motif	0.7982
p.L1092I	TCGA-A5-A2K5	UCEC	TCGA	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation altering degron motif	0.6063
p.L1092I	DO41379	UCEC	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation altering degron motif	0.6063
p.I55T	TCGA-AA-3862	COAD	TCGA	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation altering degron motif	0.5966
p.I55T	DO8706	COAD	ICGC	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation altering degron motif	0.5966
p.I1099T	TCGA-AP-A059	UCEC	TCGA	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation altering degron motif	0.7078
p.I1099T	DO41361	UCEC	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation altering degron motif	0.7078
p.S62Y	TCGA-B5-A0JY	UCEC	TCGA	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation blocking phosphorylation signal	0.75
p.S62Y	DO43041	UCEC	ICGC	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation blocking phosphorylation signal	0.75
p.P1130T	TCGA-C8-A26Y	BRCA	TCGA	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.25
p.P1130T	DO1273	BRCA	ICGC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.25
p.V1102L	TCGA-CC-A7II	LIHC	TCGA	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.2778
p.V1102L	DO52182	LIHC	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.2778
p.P44L	TCGA-D1-A174	UCEC	TCGA	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation rewiring degron network	0.1389
p.P44L	DO233908	GACA	ICGC	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation rewiring degron network	0.1389
p.P44L	DO40900	UCEC	ICGC	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation rewiring degron network	0.1389
p.H1134Y	TCGA-D3-A3MV	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1389
p.H1134Y	TCGA-GN-A269	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1389
p.H1134Y	DO37727	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1389
p.H1134Y	DO37483	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1389
p.S60L	TCGA-DA-A95Y	SKCM	TCGA	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation altering degron motif	0.8778
p.S60L	DO223908	SKCM	ICGC	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation altering degron motif	0.8778
p.I1135V	TCGA-DI-A1BU	UCEC	TCGA	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1111
p.I1135V	DO42023	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1111
p.A1117S	TCGA-DX-A6YV	SARC	TCGA	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1667
p.A1117S	DO220011	SARC	ICGC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1667
p.S1114L	TCGA-EE-A2MM	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.0833
p.S1114L	DO52481	COCA	ICGC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.0833
p.S1114L	DO234158	ESAD	ICGC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.0833
p.S1114L	DO222678	MELA	ICGC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.0833
p.S1114L	DO37770	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.0833
p.A53T	TCGA-EO-A22U	UCEC	TCGA	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation altering degron motif	0.6028
p.A53T	DO43755	UCEC	ICGC	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation altering degron motif	0.6028
p.D1110A	TCGA-EO-A3B0	UCEC	TCGA	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.0556
p.D1110A	DO219773	UCEC	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.0556
p.D1133H	TCGA-ER-A198	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1667
p.D1133H	DO47563	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1667
p.L48F	TCGA-L9-A8F4	LUAD	TCGA	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation rewiring degron network	0.25
p.L48F	DO49876	LUAD	ICGC	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation rewiring degron network	0.25
p.S1126P	TCGA-W3-AA1R	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation altering degron motif	0.6752
p.S1126P	DO51275	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation altering degron motif	0.6752
p.P1130S	TCGA-WE-AAA0	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.25
p.P1130S	DO51294	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.25
p.T1118P	TCGA-XF-A9T3	BLCA	TCGA	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1944
p.T1118P	DO51922	BLCA	ICGC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1944
p.A53V	DO218669	BRCA	ICGC	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation altering degron motif	0.5825
p.P1130L	DO223555	CLLE	ICGC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.25
p.D1110E	DO230334	COCA	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.0556
p.D1110E	DO229010	COCA	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.0556
p.D1110E	DO229013	COCA	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.0556
p.D1110E	DO229016	COCA	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.0556
p.D1110E	DO229003	COCA	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.0556
p.D1110E	DO229005	COCA	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.0556
p.D1110E	DO223033	ESCA	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.0556
p.D1110E	DO231114	LUSC	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.0556
p.D1110E	DO231120	LUSC	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.0556
p.D47Y	DO229045	LICA	ICGC	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation rewiring degron network	0.2222
p.D47A	DO45229	LIRI	ICGC	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation rewiring degron network	0.2222
p.G46E	DO222702	MELA	ICGC	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation rewiring degron network	0.1944
p.D1113N	DO222843	MELA	ICGC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.0556
p.P63S	DO46673	PACA	ICGC	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation rewiring degron network	0.2778
p.P1131L	DO229459	SKCA	ICGC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.2222
p.D1103G	SIDM00899	Pancreatic Carcinoma	GDSC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.25
p.D1103G	ACH-000222	Pancreatic Cancer	CCLE	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.25
p.D1103G	AsPC-1	pancreas	COSMIC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.25
p.V58I	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation altering degron motif	0.7076
p.V58I	ACH-000980	Lung Cancer	CCLE	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation altering degron motif	0.7076
p.V58I	NCI-H1155	lung	COSMIC	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation altering degron motif	0.7076
p.D1110N	SIDM00154	Mesothelioma	GDSC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.0556
p.D1110N	SIDM00954	Breast Carcinoma	GDSC	LREPLAPIT	DEG_APCC_DBOX_1	1092:1100	Mutation rewiring degron network	0.0556
p.D1129N	SIDM01228	Melanoma	GDSC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.2778
p.D1129N	ACH-001024	Skin Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.2778
p.D1129N	CHL-1	skin	COSMIC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.2778
p.D1133V	ACH-000593	Bladder Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.1667
p.R65I	ACH-001991	Primary	CCLE	DDASIFPVPSA	DEG_COP1_1	51:61	Mutation rewiring degron network	0.2222
p.S1121F	NCI-H630	large intestine	COSMIC	AHSSS	DEG_SPOP_SBC_1	1123:1127	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FER1L6

UniProt ID: Q2WGJ9

Entrez ID: 654463

Protein name: Fer-1-like protein 6

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FER1L6 in