DegronMD

Uniprot ID: Q2WGJ9

Source protein: Fer-1-like protein 6

Source gene: FER1L6

Class: DEG_COP1_1

Location: 51:61

E3 ligase: COP1

DEGRON score: 0.9404

ASA_SCORE: 82.2273

COIL: 0.8698

CONS_SCORE: 0.2694

DSS_SCORE: 0.6179

HELIX: 0.1

FCONS_SCORE: 0.9706

RIG_SCORE: 0.6927

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I55T	TCGA-AA-3862	COAD	TCGA	DDASIFPVPSA	DEG_COP1_1	0.5966
p.I55T	DO8706	COAD	ICGC	DDASIFPVPSA	DEG_COP1_1	0.5966
p.S62Y	TCGA-B5-A0JY	UCEC	TCGA	DDASIFPVPSA	DEG_COP1_1	0.75
p.S62Y	DO43041	UCEC	ICGC	DDASIFPVPSA	DEG_COP1_1	0.75
p.P44L	TCGA-D1-A174	UCEC	TCGA	DDASIFPVPSA	DEG_COP1_1	0.1389
p.P44L	DO233908	GACA	ICGC	DDASIFPVPSA	DEG_COP1_1	0.1389
p.P44L	DO40900	UCEC	ICGC	DDASIFPVPSA	DEG_COP1_1	0.1389
p.S60L	TCGA-DA-A95Y	SKCM	TCGA	DDASIFPVPSA	DEG_COP1_1	0.8778
p.S60L	DO223908	SKCM	ICGC	DDASIFPVPSA	DEG_COP1_1	0.8778
p.A53T	TCGA-EO-A22U	UCEC	TCGA	DDASIFPVPSA	DEG_COP1_1	0.6028
p.A53T	DO43755	UCEC	ICGC	DDASIFPVPSA	DEG_COP1_1	0.6028
p.L48F	TCGA-L9-A8F4	LUAD	TCGA	DDASIFPVPSA	DEG_COP1_1	0.25
p.L48F	DO49876	LUAD	ICGC	DDASIFPVPSA	DEG_COP1_1	0.25
p.A53V	DO218669	BRCA	ICGC	DDASIFPVPSA	DEG_COP1_1	0.5825
p.D47Y	DO229045	LICA	ICGC	DDASIFPVPSA	DEG_COP1_1	0.2222
p.D47A	DO45229	LIRI	ICGC	DDASIFPVPSA	DEG_COP1_1	0.2222
p.G46E	DO222702	MELA	ICGC	DDASIFPVPSA	DEG_COP1_1	0.1944
p.P63S	DO46673	PACA	ICGC	DDASIFPVPSA	DEG_COP1_1	0.2778
p.V58I	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	DDASIFPVPSA	DEG_COP1_1	0.7076
p.V58I	ACH-000980	Lung Cancer	CCLE	DDASIFPVPSA	DEG_COP1_1	0.7076
p.V58I	NCI-H1155	lung	COSMIC	DDASIFPVPSA	DEG_COP1_1	0.7076
p.R65I	ACH-001991	Primary	CCLE	DDASIFPVPSA	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2WGJ9	Fer-1-like protein 6	DEG_COP1_1	51:61	DDASIFPVPSA	COP1	0.9404	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons