DegronMD

Uniprot ID: Q2WGJ9

Source protein: Fer-1-like protein 6

Source gene: FER1L6

Class: DEG_APCC_DBOX_1

Location: 1092:1100

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7943

ASA_SCORE: 79.9222

COIL: 0.8126

CONS_SCORE: 0.2782

DSS_SCORE: 0.2565

HELIX: 0.0567

FCONS_SCORE: 0.883

RIG_SCORE: 0.8334

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1097S	TCGA-44-3918	LUAD	TCGA	LREPLAPIT	DEG_APCC_DBOX_1	0.6477
p.A1097S	DO23732	LUAD	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	0.6477
p.L1092I	TCGA-A5-A2K5	UCEC	TCGA	LREPLAPIT	DEG_APCC_DBOX_1	0.6063
p.L1092I	DO41379	UCEC	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	0.6063
p.I1099T	TCGA-AP-A059	UCEC	TCGA	LREPLAPIT	DEG_APCC_DBOX_1	0.7078
p.I1099T	DO41361	UCEC	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	0.7078
p.V1102L	TCGA-CC-A7II	LIHC	TCGA	LREPLAPIT	DEG_APCC_DBOX_1	0.2778
p.V1102L	DO52182	LIHC	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	0.2778
p.D1110A	TCGA-EO-A3B0	UCEC	TCGA	LREPLAPIT	DEG_APCC_DBOX_1	0.0556
p.D1110A	DO219773	UCEC	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	0.0556
p.D1110E	DO230334	COCA	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	0.0556
p.D1110E	DO229010	COCA	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	0.0556
p.D1110E	DO229013	COCA	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	0.0556
p.D1110E	DO229016	COCA	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	0.0556
p.D1110E	DO229003	COCA	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	0.0556
p.D1110E	DO229005	COCA	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	0.0556
p.D1110E	DO223033	ESCA	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	0.0556
p.D1110E	DO231114	LUSC	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	0.0556
p.D1110E	DO231120	LUSC	ICGC	LREPLAPIT	DEG_APCC_DBOX_1	0.0556
p.D1103G	SIDM00899	Pancreatic Carcinoma	GDSC	LREPLAPIT	DEG_APCC_DBOX_1	0.25
p.D1103G	ACH-000222	Pancreatic Cancer	CCLE	LREPLAPIT	DEG_APCC_DBOX_1	0.25
p.D1103G	AsPC-1	pancreas	COSMIC	LREPLAPIT	DEG_APCC_DBOX_1	0.25
p.D1110N	SIDM00154	Mesothelioma	GDSC	LREPLAPIT	DEG_APCC_DBOX_1	0.0556
p.D1110N	SIDM00954	Breast Carcinoma	GDSC	LREPLAPIT	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2WGJ9	Fer-1-like protein 6	DEG_APCC_DBOX_1	1092:1100	LREPLAPIT	APC,CDC20,FZR1	0.7943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons