DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
AHSSS
Uniprot ID:
C9J798
Source protein:
Ras GTPase-activating protein 4B
Source gene:
RASA4B
Class:
DEG_SPOP_SBC_1
Location:
782:786
E3 ligase:
SPOP
DEGRON score:
0.6288
ASA_SCORE:
58.82
COIL:
0.5292
CONS_SCORE:
0.428
DSS_SCORE:
0.7051
HELIX:
0.4668
FCONS_SCORE:
1.1366
RIG_SCORE:
0.5792
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RASA4B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AHSSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15015
Zinc finger protein 646
DEG_SPOP_SBC_1
903:907
AHSSS
SPOP
0.9691
More...
O60269
G protein-regulated inducer of neurite outgrowth 2
DEG_SPOP_SBC_1
206:210
AHSSS
SPOP
0.855
More...
O95425
Supervillin
DEG_SPOP_SBC_1
249:253
AHSSS
SPOP
0.9277
More...
P51825
AF4/FMR2 family member 1
DEG_SPOP_SBC_1
464:468
AHSSS
SPOP
0.8527
More...
Q13416
Origin recognition complex subunit 2
DEG_SPOP_SBC_1
246:250
AHSSS
SPOP
0.8711
More...
Q13586
Stromal interaction molecule 1
DEG_SPOP_SBC_1
397:401
AHSSS
SPOP
0.9518
More...
Q6UVJ0
Spindle assembly abnormal protein 6 homolog
DEG_SPOP_SBC_1
498:502
AHSSS
SPOP
0.9472
More...
Q05952
Nuclear transition protein 2
DEG_SPOP_SBC_1
62:66
AHSSS
SPOP
0.9869
More...
Q8IX06
Putative exonuclease GOR
DEG_SPOP_SBC_1
211:215
AHSSS
SPOP
0.5387
More...
Q8WYN3
Cysteine/serine-rich nuclear protein 3
DEG_SPOP_SBC_1
297:301
AHSSS
SPOP
0.8601
More...
Q9ULI4
Kinesin-like protein KIF26A
DEG_SPOP_SBC_1
1445:1449
AHSSS
SPOP
0.9988
More...
A6NMT0
Homeobox protein DBX1
DEG_SPOP_SBC_1
314:318
AHSSS
SPOP
0.9343
More...
C9J798
Ras GTPase-activating protein 4B
DEG_SPOP_SBC_1
782:786
AHSSS
SPOP
0.6288
More...
Q2WGJ9
Fer-1-like protein 6
DEG_SPOP_SBC_1
1123:1127
AHSSS
SPOP
0.7335
More...
A6NNC1
Putative POM121-like protein 1-like
DEG_SPOP_SBC_1
422:426
AHSSS
SPOP
0.9446
More...
A6NNC1
Putative POM121-like protein 1-like
DEG_SPOP_SBC_1
694:698
AHSSS
SPOP
0.9817
More...
P0C879
Putative uncharacterized protein FLJ43185
DEG_SPOP_SBC_1
76:80
AHSSS
SPOP
0.9484
More...