DegronMD

Uniprot ID: A6NMT0

Source protein: Homeobox protein DBX1

Source gene: DBX1

Class: LIG_APCC_ABBA_1

Location: 259:264

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9852

ASA_SCORE: 99.5167

COIL: 0.9417

CONS_SCORE: 0.5404

DSS_SCORE: 0.7446

HELIX: 0.0422

FCONS_SCORE: 1.2267

RIG_SCORE: 0.62

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R272C	TCGA-2W-A8YY	CESC	TCGA	LNPHPD	LIG_APCC_ABBA_1	0.1111
p.F262Y	TCGA-62-A46R	LUAD	TCGA	LNPHPD	LIG_APCC_ABBA_1	0.7528
p.F262Y	DO45355	LUAD	ICGC	LNPHPD	LIG_APCC_ABBA_1	0.7528
p.K265R	TCGA-86-6851	LUAD	TCGA	LNPHPD	LIG_APCC_ABBA_1	0.3056
p.M273I	TCGA-EE-A3J5	SKCM	TCGA	LNPHPD	LIG_APCC_ABBA_1	0.0833
p.Q270H	DO219007	BLCA	ICGC	LNPHPD	LIG_APCC_ABBA_1	0.1667
p.Q270H	ACH-001336	Cervical Cancer	CCLE	LNPHPD	LIG_APCC_ABBA_1	0.1667
p.P254S	DO217836	ORCA	ICGC	LNPHPD	LIG_APCC_ABBA_1	0.1944
p.P261S	DO43755	UCEC	ICGC	LNPHPD	LIG_APCC_ABBA_1	0.6752
p.L259F	DO42472	UCEC	ICGC	LNPHPD	LIG_APCC_ABBA_1	0.587
p.L259F	ACH-001618	Leukemia	CCLE	LNPHPD	LIG_APCC_ABBA_1	0.587
p.H262Y	SIDM00721	Small Cell Lung Carcinoma	GDSC	LNPHPD	LIG_APCC_ABBA_1	0.6118
p.H262Y	ACH-002171	Lung Cancer	CCLE	LNPHPD	LIG_APCC_ABBA_1	0.6118
p.H262Y	NCI-H250	lung	COSMIC	LNPHPD	LIG_APCC_ABBA_1	0.6118
p.P256H	ACH-001111	Lymphoma	CCLE	LNPHPD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NMT0	Homeobox protein DBX1	LIG_APCC_ABBA_1	259:264	LNPHPD	APC,CDC20,FZR1	0.9852	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons