DegronMD

Uniprot ID: A6NMT0

Source protein: Homeobox protein DBX1

Source gene: DBX1

Class: DEG_SCF_FBW7_1

Location: 17:24

E3 ligase: FBXW7

DEGRON score: 0.9855

ASA_SCORE: 73.4125

COIL: 0.8709

CONS_SCORE: 0.4312

DSS_SCORE: 0.3755

HELIX: 0.0595

FCONS_SCORE: 0.9402

RIG_SCORE: 0.7434

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T20M	TCGA-AJ-A5DW	UCEC	TCGA	LRPTPTLT	DEG_SCF_FBW7_1	0.7423
p.T20M	DO50075	UCEC	ICGC	LRPTPTLT	DEG_SCF_FBW7_1	0.7423
p.A8V	TCGA-UT-A88E	MESO	TCGA	LRPTPTLT	DEG_SCF_FBW7_1	0.0833
p.A11S	DO50449	ESAD	ICGC	LRPTPTLT	DEG_SCF_FBW7_1	0.1667
p.A11S	ACH-000258	Breast Cancer	CCLE	LRPTPTLT	DEG_SCF_FBW7_1	0.1667
p.S34F	DO222578	MELA	ICGC	LRPTPTLT	DEG_SCF_FBW7_1	0.0556
p.P9L	DO229259	THCA	ICGC	LRPTPTLT	DEG_SCF_FBW7_1	0.1111
p.S28F	SIDM01059	Melanoma	GDSC	LRPTPTLT	DEG_SCF_FBW7_1	0.2222
p.R18L	ACH-002066	Sarcoma	CCLE	LRPTPTLT	DEG_SCF_FBW7_1	0.7316

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NMT0	Homeobox protein DBX1	DEG_SCF_FBW7_1	17:24	LRPTPTLT	FBXW7	0.9855	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons