DegronMD

Uniprot ID: A6NMT0

Source protein: Homeobox protein DBX1

Source gene: DBX1

Class: LIG_APCC_ABBAyCdc20_2

Location: 184:190

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9756

ASA_SCORE: 82.5714

COIL: 0.7133

CONS_SCORE: 0.6493

DSS_SCORE: 0.3966

HELIX: 0.1619

FCONS_SCORE: 1.0529

RIG_SCORE: 0.8297

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F200L	TCGA-38-4625	LUAD	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.F200L	DO23952	LUAD	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D190N	TCGA-BS-A0UF	UCEC	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D190N	TCGA-EO-A22X	UCEC	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D190N	DO43907	UCEC	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D190N	DO41488	UCEC	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.6932
p.R179Q	TCGA-CK-5913	COAD	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R179Q	TCGA-D1-A16J	UCEC	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R179Q	DO8826	COAD	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R179Q	DO43033	UCEC	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.F200Y	TCGA-EY-A1GD	UCEC	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.F200Y	DO42129	UCEC	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R175C	TCGA-FI-A2D5	UCEC	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R175C	DO41331	UCEC	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.F188L	TCGA-HF-A5NB	STAD	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.6981
p.F188L	DO229019	LICA	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.6981
p.F188L	DO50127	STAD	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.6981
p.A174T	TCGA-VQ-A91K	STAD	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A174T	DO51785	STAD	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A186T	DO222492	COCA	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.6028
p.R193W	DO233088	GACA	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.25
p.A195E	DO229009	LICA	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NMT0	Homeobox protein DBX1	LIG_APCC_ABBAyCdc20_2	184:190	RRAVFSD	APC,CDC20,FZR1	0.9756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons