DegronMD - Q14896(MYBPC3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y806S	TCGA-25-1326	OV	TCGA	PPAY	ITCH	794:797	Mutation rewiring degron network	0.0833
p.Y806S	DO28154	OV	ICGC	PPAY	ITCH	794:797	Mutation rewiring degron network	0.0833
p.R945L	TCGA-DA-A1I5	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	955:959	Mutation rewiring degron network	0.0556
p.R945L	DO37447	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	955:959	Mutation rewiring degron network	0.0556
p.G951E	TCGA-EE-A2GI	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	955:959	Mutation rewiring degron network	0.2222
p.G951E	DO37410	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	955:959	Mutation rewiring degron network	0.2222
p.Q965H	TCGA-EO-A22U	UCEC	TCGA	PVTTT	DEG_SPOP_SBC_1	955:959	Mutation rewiring degron network	0.1667
p.Q965H	DO43755	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	955:959	Mutation rewiring degron network	0.1667
p.H947P	TCGA-S3-AA15	BRCA	TCGA	PVTTT	DEG_SPOP_SBC_1	955:959	Mutation rewiring degron network	0.1111
p.H947P	DO51226	BRCA	ICGC	PVTTT	DEG_SPOP_SBC_1	955:959	Mutation rewiring degron network	0.1111
p.P1161H	DO228986	LICA	ICGC	PPNY	ITCH	1169:1172	Mutation rewiring degron network	0.1111
p.P1169T	SIDM02050	Colorectal Carcinoma	GDSC	PPNY	ITCH	1169:1172	Mutation altering degron motif	0.7031
p.T957S	SIDM00135	Breast Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	955:959	Mutation altering degron motif	0.6005
p.T1166I	SIDM00545	Melanoma	GDSC	PPNY	ITCH	1169:1172	Mutation rewiring degron network	0.25
p.T1166I	ACH-000987	Skin Cancer	CCLE	PPNY	ITCH	1169:1172	Mutation rewiring degron network	0.25
p.T1166I	Mewo	skin	COSMIC	PPNY	ITCH	1169:1172	Mutation rewiring degron network	0.25
p.F1159C	SIDM00789	Colorectal Carcinoma	GDSC	PPNY	ITCH	1169:1172	Mutation rewiring degron network	0.0556
p.F1159C	ACH-000997	Colon/Colorectal Cancer	CCLE	PPNY	ITCH	1169:1172	Mutation rewiring degron network	0.0556
p.F1159C	ACH-001061	Colon/Colorectal Cancer	CCLE	PPNY	ITCH	1169:1172	Mutation rewiring degron network	0.0556
p.F1159C	HCT-15	large intestine	COSMIC	PPNY	ITCH	1169:1172	Mutation rewiring degron network	0.0556
p.A954V	SIDM00945	Colorectal Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	955:959	Mutation rewiring degron network	0.3056
p.A954V	ACH-000895	Colon/Colorectal Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	955:959	Mutation rewiring degron network	0.3056

Kaplan plot for MYBPC3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYBPC3

UniProt ID: Q14896

Entrez ID: 4607

Protein name: Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYBPC3 in