DegronMD

Uniprot ID: Q14896

Source protein: Myosin-binding protein C, cardiac-type

Source gene: MYBPC3

Class: DEG_SPOP_SBC_1

Location: 955:959

E3 ligase: SPOP

DEGRON score: 0.8503

ASA_SCORE: 67.68

COIL: 0.7814

CONS_SCORE: 0.3823

DSS_SCORE: 0.5248

HELIX: 0.015

FCONS_SCORE: 0.7508

RIG_SCORE: 0.6938

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R945L	TCGA-DA-A1I5	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	0.0556
p.R945L	DO37447	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	0.0556
p.G951E	TCGA-EE-A2GI	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	0.2222
p.G951E	DO37410	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	0.2222
p.Q965H	TCGA-EO-A22U	UCEC	TCGA	PVTTT	DEG_SPOP_SBC_1	0.1667
p.Q965H	DO43755	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1667
p.H947P	TCGA-S3-AA15	BRCA	TCGA	PVTTT	DEG_SPOP_SBC_1	0.1111
p.H947P	DO51226	BRCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1111
p.T957S	SIDM00135	Breast Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.6005
p.A954V	SIDM00945	Colorectal Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.3056
p.A954V	ACH-000895	Colon/Colorectal Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NKB5	Pecanex-like protein 2	DEG_SPOP_SBC_1	2000:2004	PVTTT	SPOP	0.9571	More...
O43283	Mitogen-activated protein kinase kinase kinase 13	DEG_SPOP_SBC_1	63:67	PVTTT	SPOP	0.9958	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2870:2874	PVTTT	SPOP	0.5381	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2876:2880	PVTTT	SPOP	0.9639	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2882:2886	PVTTT	SPOP	0.8697	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2889:2893	PVTTT	SPOP	0.991	More...
P18583	Protein SON	DEG_SPOP_SBC_1	507:511	PVTTT	SPOP	0.6512	More...
P27540	Aryl hydrocarbon receptor nuclear translocator	DEG_SPOP_SBC_1	530:534	PVTTT	SPOP	0.9876	More...
P36956	Sterol regulatory element-binding protein 1	DEG_SPOP_SBC_1	224:228	PVTTT	SPOP	0.9066	More...
P49848	Transcription initiation factor TFIID subunit 6	DEG_SPOP_SBC_1	570:574	PVTTT	SPOP	0.5016	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3488:3492	PVTTT	SPOP	0.525	More...
Q14896	Myosin-binding protein C, cardiac-type	DEG_SPOP_SBC_1	955:959	PVTTT	SPOP	0.8503	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	33135:33139	PVTTT	SPOP	0.9908	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	203:207	PVTTT	SPOP	0.9927	More...
Q9Y6V0	Protein piccolo	DEG_SPOP_SBC_1	665:669	PVTTT	SPOP	0.9936	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	616:620	PVTTT	SPOP	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons