DegronMD - P12111(COL6A3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I1640T	TCGA-29-1688	OV	TCGA	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation rewiring degron network	0.0833
p.P2870S	TCGA-43-A56V	LUSC	TCGA	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation altering degron motif	0.6752
p.P2903T	TCGA-49-4487	LUAD	TCGA	PVTTT	DEG_SPOP_SBC_1	2889:2893	Mutation rewiring degron network	0.0556
p.A1618T	TCGA-61-2096	OV	TCGA	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation rewiring degron network	0.1389
p.Q3085E	TCGA-78-8640	LUAD	TCGA	ASSST	DEG_SPOP_SBC_1	3090:3094	Mutation rewiring degron network	0.1944
p.T1627A	TCGA-86-8669	LUAD	TCGA	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation altering degron motif	0.7139
p.T2880M	TCGA-A2-A0YM	BRCA	TCGA	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7423
p.K1636N	TCGA-AA-3984	COAD	TCGA	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation substituting flanking lysine	0.3056
p.K1636N	TCGA-EO-A22X	UCEC	TCGA	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation substituting flanking lysine	0.3056
p.T2879M	TCGA-AF-2687	READ	TCGA	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7423
p.T2879M	TCGA-EI-6882	READ	TCGA	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7423
p.T2879M	SIDM00422	Hodgkin's Lymphoma	GDSC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7423
p.V3099A	TCGA-AX-A0J0	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	3090:3094	Mutation rewiring degron network	0.1944
p.E1634K	TCGA-B5-A3FA	UCEC	TCGA	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation rewiring degron network	0.25
p.T3094A	TCGA-CV-7248	HNSC	TCGA	ASSST	DEG_SPOP_SBC_1	3090:3094	Mutation altering degron motif	0.7139
p.K1635R	TCGA-DD-A11C	LIHC	TCGA	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation substituting flanking lysine	0.3333
p.V2897A	TCGA-E6-A1LX	UCEC	TCGA	PVTTT	DEG_SPOP_SBC_1	2889:2893	Mutation rewiring degron network	0.2222
p.P3084S	TCGA-ER-A19E	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	3090:3094	Mutation rewiring degron network	0.1667
p.P3086S	TCGA-GN-A266	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	3090:3094	Mutation rewiring degron network	0.2222
p.P2876L	TCGA-IB-7651	PAAD	TCGA	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7582
p.P2876L	TCGA-UF-A7JO	HNSC	TCGA	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7582
p.T2887S	TCGA-WE-A8K1	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation rewiring degron network	0.1389
p.T2887S	TCGA-WE-A8K1	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	2882:2886	Mutation rewiring degron network	0.3056
p.T2887S	TCGA-WE-A8K1	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	2889:2893	Mutation rewiring degron network	0.2778
p.L1641P	DO1608	BRCA	ICGC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation rewiring degron network	0.0556
p.T2869I	DO222990	BTCA	ICGC	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation rewiring degron network	0.3056
p.T2869I	DO222990	BTCA	ICGC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation rewiring degron network	0.1389
p.T2869I	DO229013	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation rewiring degron network	0.3056
p.T2869I	DO229013	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation rewiring degron network	0.1389
p.T2869I	DO229016	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation rewiring degron network	0.3056
p.T2869I	DO229016	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation rewiring degron network	0.1389
p.T2869I	DO229003	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation rewiring degron network	0.3056
p.T2869I	DO229003	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation rewiring degron network	0.1389
p.T2869I	DO229005	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation rewiring degron network	0.3056
p.T2869I	DO229005	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation rewiring degron network	0.1389
p.T2869I	DO234203	ESAD	ICGC	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation rewiring degron network	0.3056
p.T2869I	DO234203	ESAD	ICGC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation rewiring degron network	0.1389
p.T2869I	DO230659	LAML	ICGC	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation rewiring degron network	0.3056
p.T2869I	DO230659	LAML	ICGC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation rewiring degron network	0.1389
p.T2869I	DO230937	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation rewiring degron network	0.3056
p.T2869I	DO230937	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation rewiring degron network	0.1389
p.T2869I	DO230950	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation rewiring degron network	0.3056
p.T2869I	DO230950	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation rewiring degron network	0.1389
p.T2869I	DO230990	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation rewiring degron network	0.3056
p.T2869I	DO230990	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation rewiring degron network	0.1389
p.T2869I	DO52346	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation rewiring degron network	0.3056
p.T2869I	DO52346	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation rewiring degron network	0.1389
p.D1638H	DO7418	CLLE	ICGC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation rewiring degron network	0.1389
p.A1619V	DO9226	COAD	ICGC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation rewiring degron network	0.1667
p.A1619V	DO49824	PRAD	ICGC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation rewiring degron network	0.1667
p.A1619V	DO41871	UCEC	ICGC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation rewiring degron network	0.1667
p.S2873R	DO50411	ESAD	ICGC	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation altering degron motif	0.7427
p.A1619T	DO234213	ESAD	ICGC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation rewiring degron network	0.1667
p.L1624I	DO233679	GACA	ICGC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation rewiring degron network	0.3056
p.T2894A	DO14806	HNSC	ICGC	PVTTT	DEG_SPOP_SBC_1	2882:2886	Mutation rewiring degron network	0.1111
p.T2894A	DO14806	HNSC	ICGC	PVTTT	DEG_SPOP_SBC_1	2889:2893	Mutation rewiring degron network	0.3056
p.T1629N	DO228976	LICA	ICGC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation altering degron motif	0.7055
p.P2886T	DO229019	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	2882:2886	Mutation altering degron motif	0.7031
p.Q2885E	DO45340	LUAD	ICGC	PVTTT	DEG_SPOP_SBC_1	2882:2886	Mutation altering degron motif	0.6744
p.Q2885H	DO231777	NBL	ICGC	PVTTT	DEG_SPOP_SBC_1	2882:2886	Mutation altering degron motif	0.7582
p.Q2865K	DO47263	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation rewiring degron network	0.1944
p.P2886S	DO37432	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	2882:2886	Mutation altering degron motif	0.6752
p.P2884S	DO47542	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	2882:2886	Mutation altering degron motif	0.6752
p.S2879Y	DO42312	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.712
p.S2879Y	DO41644	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.712
p.K2877N	DO52412	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.6918
p.K2877N	DO41799	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.6918
p.Q2865H	DO41572	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation rewiring degron network	0.1944
p.V2899A	DO41133	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	2889:2893	Mutation rewiring degron network	0.1667
p.S3093L	SIDM02017	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	3090:3094	Mutation altering degron motif	0.7667
p.A1638T	SIDM00993	Plasma Cell Myeloma	GDSC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation rewiring degron network	0.1389
p.A1638T	SIDM01439	Hepatocellular Carcinoma	GDSC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation rewiring degron network	0.1389
p.P1630S	SIDM00967	Ovarian Carcinoma	GDSC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation altering degron motif	0.5641
p.T2878A	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7139
p.T2878A	ACH-000186	Lung Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7139
p.T2878A	NCI-H2444	lung	COSMIC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7139
p.R1632L	SIDM00092	Ovarian Carcinoma	GDSC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation rewiring degron network	0.3056
p.R1632L	OVCAR-4	ovary	COSMIC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation rewiring degron network	0.3056
p.M3098T	SIDM00686	Endometrial Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	3090:3094	Mutation rewiring degron network	0.2222
p.M3098T	ACH-000293	Endometrial/Uterine Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	3090:3094	Mutation rewiring degron network	0.2222
p.M3098T	KLE	endometrium	COSMIC	ASSST	DEG_SPOP_SBC_1	3090:3094	Mutation rewiring degron network	0.2222
p.T2887I	SIDM00806	Osteosarcoma	GDSC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation rewiring degron network	0.1389
p.T2887I	SIDM00806	Osteosarcoma	GDSC	PVTTT	DEG_SPOP_SBC_1	2882:2886	Mutation rewiring degron network	0.3056
p.T2887I	SIDM00806	Osteosarcoma	GDSC	PVTTT	DEG_SPOP_SBC_1	2889:2893	Mutation rewiring degron network	0.2778
p.T2887I	SIDM00085	Glioma	GDSC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation rewiring degron network	0.1389
p.T2887I	SIDM00085	Glioma	GDSC	PVTTT	DEG_SPOP_SBC_1	2882:2886	Mutation rewiring degron network	0.3056
p.T2887I	SIDM00085	Glioma	GDSC	PVTTT	DEG_SPOP_SBC_1	2889:2893	Mutation rewiring degron network	0.2778
p.T2887I	ACH-000613	Bone Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation rewiring degron network	0.1389
p.T2887I	ACH-000613	Bone Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	2882:2886	Mutation rewiring degron network	0.3056
p.T2887I	ACH-000613	Bone Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	2889:2893	Mutation rewiring degron network	0.2778
p.T2887I	ACH-001001	Bone Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation rewiring degron network	0.1389
p.T2887I	ACH-001001	Bone Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	2882:2886	Mutation rewiring degron network	0.3056
p.T2887I	ACH-001001	Bone Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	2889:2893	Mutation rewiring degron network	0.2778
p.T2887I	HOS	bone	COSMIC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation rewiring degron network	0.1389
p.T2887I	HOS	bone	COSMIC	PVTTT	DEG_SPOP_SBC_1	2882:2886	Mutation rewiring degron network	0.3056
p.T2887I	HOS	bone	COSMIC	PVTTT	DEG_SPOP_SBC_1	2889:2893	Mutation rewiring degron network	0.2778
p.P3082R	SIDM00335	Endometrial Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	3090:3094	Mutation rewiring degron network	0.1111
p.P3082R	SIDM00438	B-Lymphoblastic Leukemia	GDSC	ASSST	DEG_SPOP_SBC_1	3090:3094	Mutation rewiring degron network	0.1111
p.P3082R	SIDM00807	Bladder Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	3090:3094	Mutation rewiring degron network	0.1111
p.P1630H	SIDM00487	Colorectal Carcinoma	GDSC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation altering degron motif	0.6583
p.P1630H	ACH-000963	Colon/Colorectal Cancer	CCLE	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation altering degron motif	0.6583
p.P1630H	CCK-81	large intestine	COSMIC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation altering degron motif	0.6583
p.K2888M	SIDM00989	Bladder Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation substituting flanking lysine	0.2222
p.K2888M	ACH-000802	Bladder Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation substituting flanking lysine	0.2222
p.K2888M	BFTC-905	urinary tract	COSMIC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation substituting flanking lysine	0.2222
p.K2888N	ACH-000973	Bladder Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation substituting flanking lysine	0.2222
p.D1624N	TGBC24TKB	biliary tract	COSMIC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation rewiring degron network	0.3056
p.K2872T	HCC2998	large intestine	COSMIC	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation altering degron motif	0.7306
p.G1621D	NCI-H1155	lung	COSMIC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation rewiring degron network	0.2222
p.M2892T	KLE	endometrium	COSMIC	PVTTT	DEG_SPOP_SBC_1	2889:2893	Mutation altering degron motif	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL6A3

UniProt ID: P12111

Entrez ID: 1293

Protein name: Collagen alpha-3(VI) chain

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL6A3 in