DegronMD - P12111(COL6A3)

FUNCTION: Collagen VI acts as a cell-binding protein.

GO - Biological processes (BP): cell adhesion [GO:0007155]; muscle organ development [GO:0007517]

GO - Molecular function (MF): extracellular matrix structural constituent conferring tensile strength [GO:0030020]; serine-type endopeptidase inhibitor activity [GO:0004867]

GO - Cellular component (CC): collagen-containing extracellular matrix [GO:0062023]; collagen type VI trimer [GO:0005589]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO... View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S3093L	SIDM02017	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	3090:3094	Mutation altering degron motif	0.7667
p.P2876L	TCGA-IB-7651	PAAD	TCGA	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7582
p.P2876L	TCGA-UF-A7JO	HNSC	TCGA	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7582
p.Q2885H	DO231777	NBL	ICGC	PVTTT	DEG_SPOP_SBC_1	2882:2886	Mutation altering degron motif	0.7582
p.S2873R	DO50411	ESAD	ICGC	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation altering degron motif	0.7427
p.T2880M	TCGA-A2-A0YM	BRCA	TCGA	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7423
p.T2879M	TCGA-AF-2687	READ	TCGA	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7423
p.T2879M	TCGA-EI-6882	READ	TCGA	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7423
p.T2879M	SIDM00422	Hodgkin's Lymphoma	GDSC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7423
p.M2892T	KLE	endometrium	COSMIC	PVTTT	DEG_SPOP_SBC_1	2889:2893	Mutation altering degron motif	0.7423
p.K2872T	HCC2998	large intestine	COSMIC	PVTTT	DEG_SPOP_SBC_1	2870:2874	Mutation altering degron motif	0.7306
p.T1627A	TCGA-86-8669	LUAD	TCGA	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation altering degron motif	0.7139
p.T3094A	TCGA-CV-7248	HNSC	TCGA	ASSST	DEG_SPOP_SBC_1	3090:3094	Mutation altering degron motif	0.7139
p.T2878A	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7139
p.T2878A	ACH-000186	Lung Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7139
p.T2878A	NCI-H2444	lung	COSMIC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.7139
p.S2879Y	DO42312	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.712
p.S2879Y	DO41644	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	2876:2880	Mutation altering degron motif	0.712
p.T1629N	DO228976	LICA	ICGC	VDTPPPS	DEG_SCF_FBW7_1	1625:1631	Mutation altering degron motif	0.7055
p.P2886T	DO229019	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	2882:2886	Mutation altering degron motif	0.7031

Showing 1 to 20 of 110 entries

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Kaplan plot for COL6A3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL6A3

UniProt ID: P12111

Entrez ID: 1293

Protein name: Collagen alpha-3(VI) chain

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL6A3 in