DegronMD

Uniprot ID: P12111

Source protein: Collagen alpha-3

Source gene: COL6A3

Class: DEG_SCF_FBW7_1

Location: 1625:1631

E3 ligase: FBXW7

DEGRON score: 0.7554

ASA_SCORE: 79.5571

COIL: 0.9494

CONS_SCORE: 0.4221

DSS_SCORE: 0.7737

HELIX: 0.011

FCONS_SCORE: 0.9343

RIG_SCORE: 0.5768

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1640T	TCGA-29-1688	OV	TCGA	VDTPPPS	DEG_SCF_FBW7_1	0.0833
p.A1618T	TCGA-61-2096	OV	TCGA	VDTPPPS	DEG_SCF_FBW7_1	0.1389
p.T1627A	TCGA-86-8669	LUAD	TCGA	VDTPPPS	DEG_SCF_FBW7_1	0.7139
p.K1636N	TCGA-AA-3984	COAD	TCGA	VDTPPPS	DEG_SCF_FBW7_1	0.3056
p.K1636N	TCGA-EO-A22X	UCEC	TCGA	VDTPPPS	DEG_SCF_FBW7_1	0.3056
p.E1634K	TCGA-B5-A3FA	UCEC	TCGA	VDTPPPS	DEG_SCF_FBW7_1	0.25
p.K1635R	TCGA-DD-A11C	LIHC	TCGA	VDTPPPS	DEG_SCF_FBW7_1	0.3333
p.L1641P	DO1608	BRCA	ICGC	VDTPPPS	DEG_SCF_FBW7_1	0.0556
p.D1638H	DO7418	CLLE	ICGC	VDTPPPS	DEG_SCF_FBW7_1	0.1389
p.A1619V	DO9226	COAD	ICGC	VDTPPPS	DEG_SCF_FBW7_1	0.1667
p.A1619V	DO49824	PRAD	ICGC	VDTPPPS	DEG_SCF_FBW7_1	0.1667
p.A1619V	DO41871	UCEC	ICGC	VDTPPPS	DEG_SCF_FBW7_1	0.1667
p.A1619T	DO234213	ESAD	ICGC	VDTPPPS	DEG_SCF_FBW7_1	0.1667
p.L1624I	DO233679	GACA	ICGC	VDTPPPS	DEG_SCF_FBW7_1	0.3056
p.T1629N	DO228976	LICA	ICGC	VDTPPPS	DEG_SCF_FBW7_1	0.7055
p.A1638T	SIDM00993	Plasma Cell Myeloma	GDSC	VDTPPPS	DEG_SCF_FBW7_1	0.1389
p.A1638T	SIDM01439	Hepatocellular Carcinoma	GDSC	VDTPPPS	DEG_SCF_FBW7_1	0.1389
p.P1630S	SIDM00967	Ovarian Carcinoma	GDSC	VDTPPPS	DEG_SCF_FBW7_1	0.5641
p.R1632L	SIDM00092	Ovarian Carcinoma	GDSC	VDTPPPS	DEG_SCF_FBW7_1	0.3056
p.R1632L	OVCAR-4	ovary	COSMIC	VDTPPPS	DEG_SCF_FBW7_1	0.3056
p.P1630H	SIDM00487	Colorectal Carcinoma	GDSC	VDTPPPS	DEG_SCF_FBW7_1	0.6583
p.P1630H	ACH-000963	Colon/Colorectal Cancer	CCLE	VDTPPPS	DEG_SCF_FBW7_1	0.6583
p.P1630H	CCK-81	large_intestine	COSMIC	VDTPPPS	DEG_SCF_FBW7_1	0.6583
p.D1624N	TGBC24TKB	biliary_tract	COSMIC	VDTPPPS	DEG_SCF_FBW7_1	0.3056
p.G1621D	NCI-H1155	lung	COSMIC	VDTPPPS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12111	Collagen alpha-3	DEG_SCF_FBW7_1	1625:1631	VDTPPPS	FBXW7	0.7554	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VDTPPPS

Degron related mutations and impact score

Drug responses associated with COL6A3 mutations

All proteins holding degron of VDTPPPS