DegronMD

Uniprot ID: P12111

Source protein: Collagen alpha-3

Source gene: COL6A3

Class: DEG_SPOP_SBC_1

Location: 2876:2880

E3 ligase: SPOP

DEGRON score: 0.9639

ASA_SCORE: 84.8

COIL: 0.7708

CONS_SCORE: 0.313

DSS_SCORE: 0.5621

HELIX: 0.0146

FCONS_SCORE: 0.8716

RIG_SCORE: 0.7261

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2880M	TCGA-A2-A0YM	BRCA	TCGA	PVTTT	DEG_SPOP_SBC_1	0.7423
p.T2879M	TCGA-AF-2687	READ	TCGA	PVTTT	DEG_SPOP_SBC_1	0.7423
p.T2879M	TCGA-EI-6882	READ	TCGA	PVTTT	DEG_SPOP_SBC_1	0.7423
p.T2879M	SIDM00422	Hodgkin's Lymphoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.7423
p.P2876L	TCGA-IB-7651	PAAD	TCGA	PVTTT	DEG_SPOP_SBC_1	0.7582
p.P2876L	TCGA-UF-A7JO	HNSC	TCGA	PVTTT	DEG_SPOP_SBC_1	0.7582
p.T2887S	TCGA-WE-A8K1	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	0.1389
p.T2869I	DO222990	BTCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.T2869I	DO229013	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.T2869I	DO229016	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.T2869I	DO229003	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.T2869I	DO229005	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.T2869I	DO234203	ESAD	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.T2869I	DO230659	LAML	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.T2869I	DO230937	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.T2869I	DO230950	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.T2869I	DO230990	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.T2869I	DO52346	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.S2879Y	DO42312	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.712
p.S2879Y	DO41644	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.712
p.K2877N	DO52412	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.6918
p.K2877N	DO41799	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.6918
p.T2878A	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.7139
p.T2878A	ACH-000186	Lung Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	0.7139
p.T2878A	NCI-H2444	lung	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.7139
p.T2887I	SIDM00806	Osteosarcoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.T2887I	SIDM00085	Glioma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.T2887I	ACH-000613	Bone Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	0.1389
p.T2887I	ACH-001001	Bone Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	0.1389
p.T2887I	HOS	bone	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.K2888M	SIDM00989	Bladder Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.2222
p.K2888M	ACH-000802	Bladder Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	0.2222
p.K2888M	BFTC-905	urinary_tract	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.2222
p.K2888N	ACH-000973	Bladder Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NKB5	Pecanex-like protein 2	DEG_SPOP_SBC_1	2000:2004	PVTTT	SPOP	0.9571	More...
O43283	Mitogen-activated protein kinase kinase kinase 13	DEG_SPOP_SBC_1	63:67	PVTTT	SPOP	0.9958	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2870:2874	PVTTT	SPOP	0.5381	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2876:2880	PVTTT	SPOP	0.9639	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2882:2886	PVTTT	SPOP	0.8697	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2889:2893	PVTTT	SPOP	0.991	More...
P18583	Protein SON	DEG_SPOP_SBC_1	507:511	PVTTT	SPOP	0.6512	More...
P27540	Aryl hydrocarbon receptor nuclear translocator	DEG_SPOP_SBC_1	530:534	PVTTT	SPOP	0.9876	More...
P36956	Sterol regulatory element-binding protein 1	DEG_SPOP_SBC_1	224:228	PVTTT	SPOP	0.9066	More...
P49848	Transcription initiation factor TFIID subunit 6	DEG_SPOP_SBC_1	570:574	PVTTT	SPOP	0.5016	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3488:3492	PVTTT	SPOP	0.525	More...
Q14896	Myosin-binding protein C, cardiac-type	DEG_SPOP_SBC_1	955:959	PVTTT	SPOP	0.8503	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	33135:33139	PVTTT	SPOP	0.9908	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	203:207	PVTTT	SPOP	0.9927	More...
Q9Y6V0	Protein piccolo	DEG_SPOP_SBC_1	665:669	PVTTT	SPOP	0.9936	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	616:620	PVTTT	SPOP	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTTT

Degron related mutations and impact score

Drug responses associated with COL6A3 mutations

All proteins holding degron of PVTTT