DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PVTTT
Uniprot ID:
A6NKB5
Source protein:
Pecanex-like protein 2
Source gene:
PCNX2
Class:
DEG_SPOP_SBC_1
Location:
2000:2004
E3 ligase:
SPOP
DEGRON score:
0.9571
ASA_SCORE:
81.8
COIL:
0.8846
CONS_SCORE:
0.3169
DSS_SCORE:
0.6363
HELIX:
0.0434
FCONS_SCORE:
0.8836
RIG_SCORE:
0.6326
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PCNX2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PVTTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NKB5
Pecanex-like protein 2
DEG_SPOP_SBC_1
2000:2004
PVTTT
SPOP
0.9571
More...
O43283
Mitogen-activated protein kinase kinase kinase 13
DEG_SPOP_SBC_1
63:67
PVTTT
SPOP
0.9958
More...
P12111
Collagen alpha-3
DEG_SPOP_SBC_1
2870:2874
PVTTT
SPOP
0.5381
More...
P12111
Collagen alpha-3
DEG_SPOP_SBC_1
2876:2880
PVTTT
SPOP
0.9639
More...
P12111
Collagen alpha-3
DEG_SPOP_SBC_1
2882:2886
PVTTT
SPOP
0.8697
More...
P12111
Collagen alpha-3
DEG_SPOP_SBC_1
2889:2893
PVTTT
SPOP
0.991
More...
P18583
Protein SON
DEG_SPOP_SBC_1
507:511
PVTTT
SPOP
0.6512
More...
P27540
Aryl hydrocarbon receptor nuclear translocator
DEG_SPOP_SBC_1
530:534
PVTTT
SPOP
0.9876
More...
P36956
Sterol regulatory element-binding protein 1
DEG_SPOP_SBC_1
224:228
PVTTT
SPOP
0.9066
More...
P49848
Transcription initiation factor TFIID subunit 6
DEG_SPOP_SBC_1
570:574
PVTTT
SPOP
0.5016
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
3488:3492
PVTTT
SPOP
0.525
More...
Q14896
Myosin-binding protein C, cardiac-type
DEG_SPOP_SBC_1
955:959
PVTTT
SPOP
0.8503
More...
Q8WZ42
Titin
DEG_SPOP_SBC_1
33135:33139
PVTTT
SPOP
0.9908
More...
Q96D42
Hepatitis A virus cellular receptor 1
DEG_SPOP_SBC_1
203:207
PVTTT
SPOP
0.9927
More...
Q9Y6V0
Protein piccolo
DEG_SPOP_SBC_1
665:669
PVTTT
SPOP
0.9936
More...
Q7Z2K8
G protein-regulated inducer of neurite outgrowth 1
DEG_SPOP_SBC_1
616:620
PVTTT
SPOP
0.9985
More...