DegronMD - O43283(MAP3K13)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q391H	TCGA-21-5782	LUSC	TCGA	FRQTLMHLD	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.0833
p.Q391H	DO27120	LUSC	ICGC	FRQTLMHLD	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.0833
p.Q426E	TCGA-22-5473	LUSC	TCGA	VLATPQET	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.1944
p.Q426E	DO26467	LUSC	ICGC	VLATPQET	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.1944
p.R430T	TCGA-62-A471	LUAD	TCGA	VLATPQET	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.0833
p.R430T	DO45347	LUAD	ICGC	VLATPQET	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.0833
p.R53Q	TCGA-A5-A2K5	UCEC	TCGA	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0556
p.R53Q	TCGA-EO-A22U	UCEC	TCGA	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0556
p.R53Q	DO43755	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0556
p.R53Q	DO41379	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0556
p.R395Q	TCGA-A5-A2K5	UCEC	TCGA	FRQTLMHLD	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.1944
p.T70M	TCGA-AN-A04C	BRCA	TCGA	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25
p.T70M	DO1280	BRCA	ICGC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25
p.T70M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25
p.T70M	ACH-002256	Leukemia	CCLE	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25
p.T70M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25
p.T421A	TCGA-AX-A1CE	UCEC	TCGA	VLATPQET	DEG_SCF_FBW7_1	414:421	Mutation altering degron motif	0.7139
p.T421A	DO42280	UCEC	ICGC	VLATPQET	DEG_SCF_FBW7_1	414:421	Mutation altering degron motif	0.7139
p.A412P	TCGA-CV-A45Z	HNSC	TCGA	FRQTLMHLD	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.2222
p.A412P	TCGA-CV-A45Z	HNSC	TCGA	VLATPQET	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.2778
p.A412P	DO52064	HNSC	ICGC	FRQTLMHLD	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.2222
p.A412P	DO52064	HNSC	ICGC	VLATPQET	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.2778
p.P63L	TCGA-D3-A51G	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation altering degron motif	0.7582
p.P63L	TCGA-D3-A8GC	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation altering degron motif	0.7582
p.P63L	DO222662	MELA	ICGC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation altering degron motif	0.7582
p.P63L	DO50281	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation altering degron motif	0.7582
p.P63L	DO47700	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation altering degron motif	0.7582
p.R397Q	TCGA-EE-A2MR	SKCM	TCGA	FRQTLMHLD	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.25
p.R397Q	DO37819	SKCM	ICGC	FRQTLMHLD	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.25
p.E58K	DO2401	BRCA	ICGC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.1944
p.P70L	DO10373	COAD	ICGC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25
p.V64I	DO227996	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation altering degron motif	0.5965
p.R404P	DO233119	GACA	ICGC	FRQTLMHLD	DEG_APCC_DBOX_1	400:408	Mutation altering degron motif	0.7512
p.M400I	DO228976	LICA	ICGC	FRQTLMHLD	DEG_APCC_DBOX_1	400:408	Mutation altering degron motif	0.7618
p.T59M	DO229060	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation blocking phosphorylation signal	0.6667
p.T59M	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation blocking phosphorylation signal	0.6667
p.R404Q	DO220891	MELA	ICGC	FRQTLMHLD	DEG_APCC_DBOX_1	400:408	Mutation altering degron motif	0.7329
p.S73R	DO49118	PACA	ICGC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.1667
p.S73I	DO232761	PBCA	ICGC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.1667
p.K76N	DO37881	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.0833
p.P414H	DO47683	SKCM	ICGC	VLATPQET	DEG_SCF_FBW7_1	414:421	Mutation altering degron motif	0.7694
p.D75V	SIDM00954	Breast Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.1111
p.D75V	ACH-001820	Breast Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.1111
p.D75V	COLO-824	breast	COSMIC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.1111
p.Q426R	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VLATPQET	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.1944
p.Q426R	PF-382	haematopoietic and lymphoid tissue	COSMIC	VLATPQET	DEG_SCF_FBW7_1	414:421	Mutation rewiring degron network	0.1944
p.V60L	ACH-000901	Lung Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25
p.M60I	DG-75	haematopoietic and lymphoid tissue	COSMIC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25
p.M60L	NB1	autonomic ganglia	COSMIC	PVTTT	DEG_SPOP_SBC_1	63:67	Mutation rewiring degron network	0.25
p.T402I	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	FRQTLMHLD	DEG_APCC_DBOX_1	400:408	Mutation altering degron motif	0.7078
p.P405S	HEC-1	endometrium	COSMIC	FRQTLMHLD	DEG_APCC_DBOX_1	400:408	Mutation altering degron motif	0.6752

Kaplan plot for MAP3K13 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP3K13

UniProt ID: O43283

Entrez ID: 9175

Protein name: Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP3K13 in