DegronMD

Uniprot ID: O43283

Source protein: Mitogen-activated protein kinase kinase kinase 13

Source gene: MAP3K13

Class: DEG_APCC_DBOX_1

Location: 400:408

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5508

ASA_SCORE: 54.2889

COIL: 0.01

CONS_SCORE: 0.4853

DSS_SCORE: 0.3935

HELIX: 0.9884

FCONS_SCORE: 1.1927

RIG_SCORE: 0.7919

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q391H	TCGA-21-5782	LUSC	TCGA	FRQTLMHLD	DEG_APCC_DBOX_1	0.0833
p.Q391H	DO27120	LUSC	ICGC	FRQTLMHLD	DEG_APCC_DBOX_1	0.0833
p.R395Q	TCGA-A5-A2K5	UCEC	TCGA	FRQTLMHLD	DEG_APCC_DBOX_1	0.1944
p.A412P	TCGA-CV-A45Z	HNSC	TCGA	FRQTLMHLD	DEG_APCC_DBOX_1	0.2222
p.A412P	DO52064	HNSC	ICGC	FRQTLMHLD	DEG_APCC_DBOX_1	0.2222
p.R397Q	TCGA-EE-A2MR	SKCM	TCGA	FRQTLMHLD	DEG_APCC_DBOX_1	0.25
p.R397Q	DO37819	SKCM	ICGC	FRQTLMHLD	DEG_APCC_DBOX_1	0.25
p.R404P	DO233119	GACA	ICGC	FRQTLMHLD	DEG_APCC_DBOX_1	0.7512
p.M400I	DO228976	LICA	ICGC	FRQTLMHLD	DEG_APCC_DBOX_1	0.7618
p.R404Q	DO220891	MELA	ICGC	FRQTLMHLD	DEG_APCC_DBOX_1	0.7329
p.T402I	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	FRQTLMHLD	DEG_APCC_DBOX_1	0.7078
p.P405S	HEC-1	endometrium	COSMIC	FRQTLMHLD	DEG_APCC_DBOX_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43283	Mitogen-activated protein kinase kinase kinase 13	DEG_APCC_DBOX_1	400:408	FRQTLMHLD	APC,CDC20,FZR1	0.5508	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons