DegronMD

Uniprot ID: O43283

Source protein: Mitogen-activated protein kinase kinase kinase 13

Source gene: MAP3K13

Class: DEG_SCF_FBW7_1

Location: 414:421

E3 ligase: FBXW7

DEGRON score: 0.8698

ASA_SCORE: 78.75

COIL: 0.7221

CONS_SCORE: 0.3226

DSS_SCORE: 0.3061

HELIX: 0.254

FCONS_SCORE: 0.8064

RIG_SCORE: 0.7751

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P414H	DO47683	SKCM	ICGC	VLATPQET	DEG_SCF_FBW7_1	0.7694
p.T421A	TCGA-AX-A1CE	UCEC	TCGA	VLATPQET	DEG_SCF_FBW7_1	0.7139
p.T421A	DO42280	UCEC	ICGC	VLATPQET	DEG_SCF_FBW7_1	0.7139
p.A412P	TCGA-CV-A45Z	HNSC	TCGA	VLATPQET	DEG_SCF_FBW7_1	0.2778
p.A412P	DO52064	HNSC	ICGC	VLATPQET	DEG_SCF_FBW7_1	0.2778
p.Q426E	TCGA-22-5473	LUSC	TCGA	VLATPQET	DEG_SCF_FBW7_1	0.1944
p.Q426E	DO26467	LUSC	ICGC	VLATPQET	DEG_SCF_FBW7_1	0.1944
p.Q426R	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VLATPQET	DEG_SCF_FBW7_1	0.1944
p.Q426R	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	VLATPQET	DEG_SCF_FBW7_1	0.1944
p.R430T	TCGA-62-A471	LUAD	TCGA	VLATPQET	DEG_SCF_FBW7_1	0.0833
p.R430T	DO45347	LUAD	ICGC	VLATPQET	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43283	Mitogen-activated protein kinase kinase kinase 13	DEG_SCF_FBW7_1	414:421	VLATPQET	FBXW7	0.8698	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons