DegronMD

Uniprot ID: O43283

Source protein: Mitogen-activated protein kinase kinase kinase 13

Source gene: MAP3K13

Class: DEG_SPOP_SBC_1

Location: 63:67

E3 ligase: SPOP

DEGRON score: 0.9958

ASA_SCORE: 81.04

COIL: 0.7906

CONS_SCORE: 0.22

DSS_SCORE: 0.4682

HELIX: 0.0516

FCONS_SCORE: 0.918

RIG_SCORE: 0.7373

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R53Q	TCGA-A5-A2K5	UCEC	TCGA	PVTTT	DEG_SPOP_SBC_1	0.0556
p.R53Q	TCGA-EO-A22U	UCEC	TCGA	PVTTT	DEG_SPOP_SBC_1	0.0556
p.R53Q	DO43755	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.0556
p.R53Q	DO41379	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.0556
p.T70M	TCGA-AN-A04C	BRCA	TCGA	PVTTT	DEG_SPOP_SBC_1	0.25
p.T70M	DO1280	BRCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.25
p.T70M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PVTTT	DEG_SPOP_SBC_1	0.25
p.T70M	ACH-002256	Leukemia	CCLE	PVTTT	DEG_SPOP_SBC_1	0.25
p.T70M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.25
p.P63L	TCGA-D3-A51G	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	0.7582
p.P63L	TCGA-D3-A8GC	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	0.7582
p.P63L	DO222662	MELA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7582
p.P63L	DO50281	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7582
p.P63L	DO47700	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7582
p.E58K	DO2401	BRCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1944
p.P70L	DO10373	COAD	ICGC	PVTTT	DEG_SPOP_SBC_1	0.25
p.V64I	DO227996	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.5965
p.T59M	DO229060	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.6667
p.T59M	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.6667
p.S73R	DO49118	PACA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1667
p.S73I	DO232761	PBCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1667
p.K76N	DO37881	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	0.0833
p.D75V	SIDM00954	Breast Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.1111
p.D75V	ACH-001820	Breast Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	0.1111
p.D75V	COLO-824	breast	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.1111
p.V60L	ACH-000901	Lung Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	0.25
p.M60I	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.25
p.M60L	NB1	autonomic_ganglia	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NKB5	Pecanex-like protein 2	DEG_SPOP_SBC_1	2000:2004	PVTTT	SPOP	0.9571	More...
O43283	Mitogen-activated protein kinase kinase kinase 13	DEG_SPOP_SBC_1	63:67	PVTTT	SPOP	0.9958	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2870:2874	PVTTT	SPOP	0.5381	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2876:2880	PVTTT	SPOP	0.9639	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2882:2886	PVTTT	SPOP	0.8697	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2889:2893	PVTTT	SPOP	0.991	More...
P18583	Protein SON	DEG_SPOP_SBC_1	507:511	PVTTT	SPOP	0.6512	More...
P27540	Aryl hydrocarbon receptor nuclear translocator	DEG_SPOP_SBC_1	530:534	PVTTT	SPOP	0.9876	More...
P36956	Sterol regulatory element-binding protein 1	DEG_SPOP_SBC_1	224:228	PVTTT	SPOP	0.9066	More...
P49848	Transcription initiation factor TFIID subunit 6	DEG_SPOP_SBC_1	570:574	PVTTT	SPOP	0.5016	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3488:3492	PVTTT	SPOP	0.525	More...
Q14896	Myosin-binding protein C, cardiac-type	DEG_SPOP_SBC_1	955:959	PVTTT	SPOP	0.8503	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	33135:33139	PVTTT	SPOP	0.9908	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	203:207	PVTTT	SPOP	0.9927	More...
Q9Y6V0	Protein piccolo	DEG_SPOP_SBC_1	665:669	PVTTT	SPOP	0.9936	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	616:620	PVTTT	SPOP	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTTT

Degron related mutations and impact score

Drug responses associated with MAP3K13 mutations

All proteins holding degron of PVTTT