DegronMD

Uniprot ID: Q8WZ42

Source protein: Titin

Source gene: TTN

Class: DEG_SPOP_SBC_1

Location: 33135:33139

E3 ligase: SPOP

DEGRON score: 0.9908

ASA_SCORE: 71.28

COIL: 0.743

CONS_SCORE: 0.3284

DSS_SCORE: 0.5534

HELIX: 0.217

FCONS_SCORE: 0.9785

RIG_SCORE: 0.7165

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L33141H	TCGA-A6-2677	COAD	TCGA	PVTTT	DEG_SPOP_SBC_1	0.2778
p.R33145W	TCGA-AP-A0LM	UCEC	TCGA	PVTTT	DEG_SPOP_SBC_1	0.1667
p.R33145L	TCGA-BR-8683	STAD	TCGA	PVTTT	DEG_SPOP_SBC_1	0.1667
p.W33134L	TCGA-EE-A2GH	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	0.3056
p.W33134L	TCGA-EE-A2M7	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	0.3056
p.V33125A	TCGA-HI-7169	PRAD	TCGA	PVTTT	DEG_SPOP_SBC_1	0.0556
p.E33148G	DO1269	BRCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.0833
p.E33126K	DO44242	BRCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.0833
p.T33137M	DO7810	COAD	ICGC	PVTTT	DEG_SPOP_SBC_1	0.8534
p.T33138N	DO45346	LUAD	ICGC	PVTTT	DEG_SPOP_SBC_1	0.8166
p.S33147R	DO23562	LUAD	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1111
p.E33144K	DO27287	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1944
p.D33129Y	DO220877	MELA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1667
p.E33148K	DO37567	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	0.0833
p.E33148K	DO41235	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.0833
p.Q33140K	DO37442	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	0.3056
p.I33142T	SIDM00971	Breast Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.25
p.I33142T	ACH-000828	Breast Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	0.25
p.I33142T	ZR-75-30	breast	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.25
p.L33126V	SKN-3	upper_aerodigestive_tract	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.0833
p.L33126V	LU-135	lung	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.0833
p.P33134L	NCI-H1105	lung	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NKB5	Pecanex-like protein 2	DEG_SPOP_SBC_1	2000:2004	PVTTT	SPOP	0.9571	More...
O43283	Mitogen-activated protein kinase kinase kinase 13	DEG_SPOP_SBC_1	63:67	PVTTT	SPOP	0.9958	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2870:2874	PVTTT	SPOP	0.5381	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2876:2880	PVTTT	SPOP	0.9639	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2882:2886	PVTTT	SPOP	0.8697	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2889:2893	PVTTT	SPOP	0.991	More...
P18583	Protein SON	DEG_SPOP_SBC_1	507:511	PVTTT	SPOP	0.6512	More...
P27540	Aryl hydrocarbon receptor nuclear translocator	DEG_SPOP_SBC_1	530:534	PVTTT	SPOP	0.9876	More...
P36956	Sterol regulatory element-binding protein 1	DEG_SPOP_SBC_1	224:228	PVTTT	SPOP	0.9066	More...
P49848	Transcription initiation factor TFIID subunit 6	DEG_SPOP_SBC_1	570:574	PVTTT	SPOP	0.5016	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3488:3492	PVTTT	SPOP	0.525	More...
Q14896	Myosin-binding protein C, cardiac-type	DEG_SPOP_SBC_1	955:959	PVTTT	SPOP	0.8503	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	33135:33139	PVTTT	SPOP	0.9908	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	203:207	PVTTT	SPOP	0.9927	More...
Q9Y6V0	Protein piccolo	DEG_SPOP_SBC_1	665:669	PVTTT	SPOP	0.9936	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	616:620	PVTTT	SPOP	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons