DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PVTTT
Uniprot ID:
Q8WZ42
Source protein:
Titin
Source gene:
TTN
Class:
DEG_SPOP_SBC_1
Location:
33135:33139
E3 ligase:
SPOP
DEGRON score:
0.9908
ASA_SCORE:
71.28
COIL:
0.743
CONS_SCORE:
0.3284
DSS_SCORE:
0.5534
HELIX:
0.217
FCONS_SCORE:
0.9785
RIG_SCORE:
0.7165
Degron related mutations and impact score
Show
10
25
50
100
entries
Search:
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T33137M
DO7810
COAD
ICGC
PVTTT
DEG_SPOP_SBC_1
0.8534
p.T33138N
DO45346
LUAD
ICGC
PVTTT
DEG_SPOP_SBC_1
0.8166
p.W33134L
TCGA-EE-A2GH
SKCM
TCGA
PVTTT
DEG_SPOP_SBC_1
0.3056
p.W33134L
TCGA-EE-A2M7
SKCM
TCGA
PVTTT
DEG_SPOP_SBC_1
0.3056
p.Q33140K
DO37442
SKCM
ICGC
PVTTT
DEG_SPOP_SBC_1
0.3056
p.P33134L
NCI-H1105
lung
COSMIC
PVTTT
DEG_SPOP_SBC_1
0.3056
p.L33141H
TCGA-A6-2677
COAD
TCGA
PVTTT
DEG_SPOP_SBC_1
0.2778
p.I33142T
SIDM00971
Breast Carcinoma
GDSC
PVTTT
DEG_SPOP_SBC_1
0.25
p.I33142T
ACH-000828
Breast Cancer
CCLE
PVTTT
DEG_SPOP_SBC_1
0.25
p.I33142T
ZR-75-30
breast
COSMIC
PVTTT
DEG_SPOP_SBC_1
0.25
p.E33144K
DO27287
LUSC
ICGC
PVTTT
DEG_SPOP_SBC_1
0.1944
p.R33145W
TCGA-AP-A0LM
UCEC
TCGA
PVTTT
DEG_SPOP_SBC_1
0.1667
p.R33145L
TCGA-BR-8683
STAD
TCGA
PVTTT
DEG_SPOP_SBC_1
0.1667
p.D33129Y
DO220877
MELA
ICGC
PVTTT
DEG_SPOP_SBC_1
0.1667
p.S33147R
DO23562
LUAD
ICGC
PVTTT
DEG_SPOP_SBC_1
0.1111
p.E33148G
DO1269
BRCA
ICGC
PVTTT
DEG_SPOP_SBC_1
0.0833
p.E33126K
DO44242
BRCA
ICGC
PVTTT
DEG_SPOP_SBC_1
0.0833
p.E33148K
DO37567
SKCM
ICGC
PVTTT
DEG_SPOP_SBC_1
0.0833
p.E33148K
DO41235
UCEC
ICGC
PVTTT
DEG_SPOP_SBC_1
0.0833
p.L33126V
SKN-3
upper_aerodigestive_tract
COSMIC
PVTTT
DEG_SPOP_SBC_1
0.0833
p.L33126V
LU-135
lung
COSMIC
PVTTT
DEG_SPOP_SBC_1
0.0833
p.V33125A
TCGA-HI-7169
PRAD
TCGA
PVTTT
DEG_SPOP_SBC_1
0.0556
Showing 1 to 22 of 22 entries
Previous
1
Next
Drug responses associated with TTN mutations
Show
10
25
50
100
entries
Search:
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
Showing 0 to 0 of 0 entries
Previous
Next
All proteins holding degron of PVTTT
Show
10
25
50
100
entries
Search:
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P27540
Aryl hydrocarbon receptor nuclear translocator
DEG_SPOP_SBC_1
530:534
PVTTT
SPOP
0.9876
More...
P12111
Collagen alpha-3
DEG_SPOP_SBC_1
2870:2874
PVTTT
SPOP
0.5381
More...
P12111
Collagen alpha-3
DEG_SPOP_SBC_1
2876:2880
PVTTT
SPOP
0.9639
More...
P12111
Collagen alpha-3
DEG_SPOP_SBC_1
2882:2886
PVTTT
SPOP
0.8697
More...
P12111
Collagen alpha-3
DEG_SPOP_SBC_1
2889:2893
PVTTT
SPOP
0.991
More...
Q7Z2K8
G protein-regulated inducer of neurite outgrowth 1
DEG_SPOP_SBC_1
616:620
PVTTT
SPOP
0.9985
More...
Q96D42
Hepatitis A virus cellular receptor 1
DEG_SPOP_SBC_1
203:207
PVTTT
SPOP
0.9927
More...
O43283
Mitogen-activated protein kinase kinase kinase 13
DEG_SPOP_SBC_1
63:67
PVTTT
SPOP
0.9958
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
3488:3492
PVTTT
SPOP
0.525
More...
Q14896
Myosin-binding protein C, cardiac-type
DEG_SPOP_SBC_1
955:959
PVTTT
SPOP
0.8503
More...
A6NKB5
Pecanex-like protein 2
DEG_SPOP_SBC_1
2000:2004
PVTTT
SPOP
0.9571
More...
Q9Y6V0
Protein piccolo
DEG_SPOP_SBC_1
665:669
PVTTT
SPOP
0.9936
More...
P18583
Protein SON
DEG_SPOP_SBC_1
507:511
PVTTT
SPOP
0.6512
More...
P36956
Sterol regulatory element-binding protein 1
DEG_SPOP_SBC_1
224:228
PVTTT
SPOP
0.9066
More...
Q8WZ42
Titin
DEG_SPOP_SBC_1
33135:33139
PVTTT
SPOP
0.9908
More...
P49848
Transcription initiation factor TFIID subunit 6
DEG_SPOP_SBC_1
570:574
PVTTT
SPOP
0.5016
More...
Showing 1 to 16 of 16 entries
Previous
1
Next