DegronMD - P27540(ARNT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P779S	TCGA-18-3409	LUSC	TCGA	FPPFSE	LIG_APCC_ABBA_1	784:789	Mutation rewiring degron network	0.1944
p.P779S	DO26444	LUSC	ICGC	FPPFSE	LIG_APCC_ABBA_1	784:789	Mutation rewiring degron network	0.1944
p.E776K	TCGA-BK-A6W3	UCEC	TCGA	FPPFSE	LIG_APCC_ABBA_1	784:789	Mutation rewiring degron network	0.1111
p.E776K	DO222984	BTCA	ICGC	FPPFSE	LIG_APCC_ABBA_1	784:789	Mutation rewiring degron network	0.1111
p.E776K	DO229373	BTCA	ICGC	FPPFSE	LIG_APCC_ABBA_1	784:789	Mutation rewiring degron network	0.1111
p.E776K	DO50076	UCEC	ICGC	FPPFSE	LIG_APCC_ABBA_1	784:789	Mutation rewiring degron network	0.1111
p.S521G	TCGA-CD-A4MG	STAD	TCGA	LAPRQQQQQTELDM	DEG_ODPH_VHL_1	499:512	Mutation rewiring degron network	0.0833
p.S521G	TCGA-CD-A4MG	STAD	TCGA	PVTTT	DEG_SPOP_SBC_1	530:534	Mutation rewiring degron network	0.0833
p.S521G	DO48009	STAD	ICGC	LAPRQQQQQTELDM	DEG_ODPH_VHL_1	499:512	Mutation rewiring degron network	0.0833
p.S521G	DO48009	STAD	ICGC	PVTTT	DEG_SPOP_SBC_1	530:534	Mutation rewiring degron network	0.0833
p.E789K	TCGA-CN-4729	HNSC	TCGA	FPPFSE	LIG_APCC_ABBA_1	784:789	Mutation altering degron motif	0.7022
p.E789K	DO16029	HNSC	ICGC	FPPFSE	LIG_APCC_ABBA_1	784:789	Mutation altering degron motif	0.7022
p.S788L	TCGA-F7-A624	HNSC	TCGA	FPPFSE	LIG_APCC_ABBA_1	784:789	Mutation altering degron motif	0.7667
p.S788L	DO44440	HNSC	ICGC	FPPFSE	LIG_APCC_ABBA_1	784:789	Mutation altering degron motif	0.7667
p.D13G	TCGA-UF-A7JT	HNSC	TCGA	EMTSDVPSL	DEG_COP1_1	9:17	Mutation altering degron motif	0.6087
p.D13G	DO219090	HNSC	ICGC	EMTSDVPSL	DEG_COP1_1	9:17	Mutation altering degron motif	0.6087
p.S26C	TCGA-XF-A9SH	BLCA	TCGA	EMTSDVPSL	DEG_COP1_1	9:17	Mutation rewiring degron network	0.0833
p.S26C	DO51913	BLCA	ICGC	EMTSDVPSL	DEG_COP1_1	9:17	Mutation rewiring degron network	0.0833
p.R516T	DO225366	BRCA	ICGC	LAPRQQQQQTELDM	DEG_ODPH_VHL_1	499:512	Mutation rewiring degron network	0.2222
p.T11I	DO218139	BTCA	ICGC	EMTSDVPSL	DEG_COP1_1	9:17	Mutation altering degron motif	0.8189
p.D511Y	DO234347	ESAD	ICGC	LAPRQQQQQTELDM	DEG_ODPH_VHL_1	499:512	Mutation altering degron motif	0.6214
p.P785S	DO48252	ESCA	ICGC	FPPFSE	LIG_APCC_ABBA_1	784:789	Mutation altering degron motif	0.5641
p.P785S	DO233731	GACA	ICGC	FPPFSE	LIG_APCC_ABBA_1	784:789	Mutation altering degron motif	0.5641
p.T532A	DO48192	ESCA	ICGC	PVTTT	DEG_SPOP_SBC_1	530:534	Mutation altering degron motif	0.7139
p.A2E	DO228986	LICA	ICGC	EMTSDVPSL	DEG_COP1_1	9:17	Mutation rewiring degron network	0.1389
p.S539R	DO229029	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	530:534	Mutation rewiring degron network	0.1944
p.A500E	DO229045	LICA	ICGC	LAPRQQQQQTELDM	DEG_ODPH_VHL_1	499:512	Mutation altering degron motif	0.7701
p.P785L	DO220906	MELA	ICGC	FPPFSE	LIG_APCC_ABBA_1	784:789	Mutation altering degron motif	0.6471
p.I21T	SIDM02072	Colorectal Carcinoma	GDSC	EMTSDVPSL	DEG_COP1_1	9:17	Mutation rewiring degron network	0.2222
p.M512T	SIDM02015	Colorectal Carcinoma	GDSC	LAPRQQQQQTELDM	DEG_ODPH_VHL_1	499:512	Mutation altering degron motif	0.7423
p.F787L	SIDM00837	Colorectal Carcinoma	GDSC	FPPFSE	LIG_APCC_ABBA_1	784:789	Mutation altering degron motif	0.6981
p.F787L	SW48	large intestine	COSMIC	FPPFSE	LIG_APCC_ABBA_1	784:789	Mutation altering degron motif	0.6981
p.E9V	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	EMTSDVPSL	DEG_COP1_1	9:17	Mutation altering degron motif	0.7693
p.E9V	NCI-H2066	lung	COSMIC	EMTSDVPSL	DEG_COP1_1	9:17	Mutation altering degron motif	0.7693
p.F785L	ACH-000958	Colon/Colorectal Cancer	CCLE	FPPFSE	LIG_APCC_ABBA_1	784:789	Mutation altering degron motif	0.6981
p.F785L	SW48	large intestine	COSMIC	FPPFSE	LIG_APCC_ABBA_1	784:789	Mutation altering degron motif	0.6981
p.T532I	ACH-001623	Brain Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	530:534	Mutation altering degron motif	0.7078

Kaplan plot for ARNT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARNT

UniProt ID: P27540

Entrez ID: 405

Protein name: Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARNT in