DegronMD

Uniprot ID: P27540

Source protein: Aryl hydrocarbon receptor nuclear translocator

Source gene: ARNT

Class: LIG_APCC_ABBA_1

Location: 784:789

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8894

ASA_SCORE: 94.6333

COIL: 0.9362

CONS_SCORE: 0.3999

DSS_SCORE: 0.8548

HELIX: 0.0368

FCONS_SCORE: 0.9463

RIG_SCORE: 0.7405

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P779S	TCGA-18-3409	LUSC	TCGA	FPPFSE	LIG_APCC_ABBA_1	0.1944
p.P779S	DO26444	LUSC	ICGC	FPPFSE	LIG_APCC_ABBA_1	0.1944
p.E776K	TCGA-BK-A6W3	UCEC	TCGA	FPPFSE	LIG_APCC_ABBA_1	0.1111
p.E776K	DO222984	BTCA	ICGC	FPPFSE	LIG_APCC_ABBA_1	0.1111
p.E776K	DO229373	BTCA	ICGC	FPPFSE	LIG_APCC_ABBA_1	0.1111
p.E776K	DO50076	UCEC	ICGC	FPPFSE	LIG_APCC_ABBA_1	0.1111
p.E789K	TCGA-CN-4729	HNSC	TCGA	FPPFSE	LIG_APCC_ABBA_1	0.7022
p.E789K	DO16029	HNSC	ICGC	FPPFSE	LIG_APCC_ABBA_1	0.7022
p.S788L	TCGA-F7-A624	HNSC	TCGA	FPPFSE	LIG_APCC_ABBA_1	0.7667
p.S788L	DO44440	HNSC	ICGC	FPPFSE	LIG_APCC_ABBA_1	0.7667
p.P785S	DO48252	ESCA	ICGC	FPPFSE	LIG_APCC_ABBA_1	0.5641
p.P785S	DO233731	GACA	ICGC	FPPFSE	LIG_APCC_ABBA_1	0.5641
p.P785L	DO220906	MELA	ICGC	FPPFSE	LIG_APCC_ABBA_1	0.6471
p.F787L	SIDM00837	Colorectal Carcinoma	GDSC	FPPFSE	LIG_APCC_ABBA_1	0.6981
p.F787L	SW48	large_intestine	COSMIC	FPPFSE	LIG_APCC_ABBA_1	0.6981
p.F785L	ACH-000958	Colon/Colorectal Cancer	CCLE	FPPFSE	LIG_APCC_ABBA_1	0.6981
p.F785L	SW48	large_intestine	COSMIC	FPPFSE	LIG_APCC_ABBA_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27540	Aryl hydrocarbon receptor nuclear translocator	LIG_APCC_ABBA_1	784:789	FPPFSE	APC,CDC20,FZR1	0.8894	More...
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	LIG_APCC_ABBA_1	712:717	FPPFSE	APC,CDC20,FZR1	0.9804	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons