DegronMD - Q9HBZ2(ARNT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P527T	TCGA-A5-A0G2	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.0833
p.L632P	TCGA-AJ-A23O	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	619:623	Mutation rewiring degron network	0.0833
p.S612F	TCGA-D9-A148	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	619:623	Mutation rewiring degron network	0.1389
p.P529S	TCGA-EE-A3AE	SKCM	TCGA	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1389
p.P529S	ACH-002396	Bone Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1389
p.P529S	Sarc9371	bone	COSMIC	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1389
p.D549N	TCGA-FD-A6TC	BLCA	TCGA	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.0833
p.P610L	TCGA-MX-A5UJ	STAD	TCGA	PATSS	DEG_SPOP_SBC_1	619:623	Mutation rewiring degron network	0.0833
p.K535N	TCGA-O2-A52S	LUSC	TCGA	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.3056
p.K535N	ACH-001786	Colon/Colorectal Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.3056
p.D538N	DO49755	BLCA	ICGC	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation altering degron motif	0.6932
p.H532R	DO6558	CLLE	ICGC	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.2222
p.S631G	DO29628	OV	ICGC	PATSS	DEG_SPOP_SBC_1	619:623	Mutation rewiring degron network	0.1111
p.S530A	DO232761	PBCA	ICGC	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1667
p.T625N	DO232224	PBCA	ICGC	PATSS	DEG_SPOP_SBC_1	619:623	Mutation rewiring degron network	0.2778
p.S619F	DO229446	SKCA	ICGC	PATSS	DEG_SPOP_SBC_1	619:623	Mutation altering degron motif	0.7982
p.E630K	DO229250	THCA	ICGC	PATSS	DEG_SPOP_SBC_1	619:623	Mutation rewiring degron network	0.1389
p.L621P	DO43290	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	619:623	Mutation altering degron motif	0.7582
p.T545M	DO41919	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1944
p.A536G	SIDM00697	Small Cell Lung Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation altering degron motif	0.754
p.A536G	ACH-000830	Lung Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation altering degron motif	0.754
p.A536G	NCI-H1436	lung	COSMIC	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation altering degron motif	0.754
p.G531R	SIDM01051	Ovarian Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1944
p.G531R	ACH-000936	Ovarian Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1944
p.G531R	EFO-27	ovary	COSMIC	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.1944
p.D609E	SIDM00154	Mesothelioma	GDSC	PATSS	DEG_SPOP_SBC_1	619:623	Mutation rewiring degron network	0.0556
p.D609E	ACH-002130	Lung Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	619:623	Mutation rewiring degron network	0.0556
p.D609E	H2795	pleura	COSMIC	PATSS	DEG_SPOP_SBC_1	619:623	Mutation rewiring degron network	0.0556
p.S526N	SIDM01588	Endometrial Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.0556
p.S526N	ACH-000993	Endometrial/Uterine Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.0556
p.G534R	ACH-000831	Endometrial/Uterine Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.2778
p.M549V	SK-N-FI	autonomic ganglia	COSMIC	AFSSS	DEG_SPOP_SBC_1	536:540	Mutation rewiring degron network	0.0833
p.R704W	GOTO	autonomic ganglia	COSMIC	FPPFSE	LIG_APCC_ABBA_1	712:717	Mutation rewiring degron network	0.1111

Kaplan plot for ARNT2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARNT2

UniProt ID: Q9HBZ2

Entrez ID: 9915

Protein name: Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2) (Class E basic helix-loop-helix protein 1) (bHLHe1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARNT2 in