DegronMD

Uniprot ID: Q9HBZ2

Source protein: Aryl hydrocarbon receptor nuclear translocator 2

Source gene: ARNT2

Class: DEG_SPOP_SBC_1

Location: 536:540

E3 ligase: SPOP

DEGRON score: 0.9671

ASA_SCORE: 71.14

COIL: 0.7504

CONS_SCORE: 0.3796

DSS_SCORE: 0.4891

HELIX: 0.0848

FCONS_SCORE: 1.0134

RIG_SCORE: 0.6324

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P527T	TCGA-A5-A0G2	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.0833
p.P529S	TCGA-EE-A3AE	SKCM	TCGA	AFSSS	DEG_SPOP_SBC_1	0.1389
p.P529S	ACH-002396	Bone Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.1389
p.P529S	Sarc9371	bone	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.1389
p.D549N	TCGA-FD-A6TC	BLCA	TCGA	AFSSS	DEG_SPOP_SBC_1	0.0833
p.K535N	TCGA-O2-A52S	LUSC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.3056
p.K535N	ACH-001786	Colon/Colorectal Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.3056
p.D538N	DO49755	BLCA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.6932
p.H532R	DO6558	CLLE	ICGC	AFSSS	DEG_SPOP_SBC_1	0.2222
p.S530A	DO232761	PBCA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.1667
p.T545M	DO41919	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.1944
p.A536G	SIDM00697	Small Cell Lung Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.754
p.A536G	ACH-000830	Lung Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.754
p.A536G	NCI-H1436	lung	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.754
p.G531R	SIDM01051	Ovarian Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.1944
p.G531R	ACH-000936	Ovarian Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.1944
p.G531R	EFO-27	ovary	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.1944
p.S526N	SIDM01588	Endometrial Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.0556
p.S526N	ACH-000993	Endometrial/Uterine Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.0556
p.G534R	ACH-000831	Endometrial/Uterine Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.2778
p.M549V	SK-N-FI	autonomic_ganglia	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	413:417	AFSSS	SPOP	0.5892	More...
O75410	Transforming acidic coiled-coil-containing protein 1	DEG_SPOP_SBC_1	547:551	AFSSS	SPOP	0.8702	More...
O94823	Phospholipid-transporting ATPase VB	DEG_SPOP_SBC_1	535:539	AFSSS	SPOP	0.6502	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	405:409	AFSSS	SPOP	0.9658	More...
Q14584	Zinc finger protein 266	DEG_SPOP_SBC_1	528:532	AFSSS	SPOP	0.6008	More...
Q8WUY3	Protein prune homolog 2	DEG_SPOP_SBC_1	842:846	AFSSS	SPOP	0.9053	More...
Q9H4D5	Nuclear RNA export factor 3	DEG_SPOP_SBC_1	513:517	AFSSS	SPOP	0.6018	More...
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	DEG_SPOP_SBC_1	536:540	AFSSS	SPOP	0.9671	More...
Q9Y2K5	R3H domain-containing protein 2	DEG_SPOP_SBC_1	286:290	AFSSS	SPOP	0.8107	More...
Q8IZF4	Adhesion G-protein coupled receptor G5	DEG_SPOP_SBC_1	520:524	AFSSS	SPOP	0.683	More...
Q8N103	T-cell activation Rho GTPase-activating protein	DEG_SPOP_SBC_1	459:463	AFSSS	SPOP	0.9042	More...
Q8N7K0	Zinc finger protein 433	DEG_SPOP_SBC_1	290:294	AFSSS	SPOP	0.5748	More...
A8MVW0	Protein FAM171A2	DEG_SPOP_SBC_1	401:405	AFSSS	SPOP	0.9201	More...
Q9BXQ6	Transmembrane protein 121B	DEG_SPOP_SBC_1	112:116	AFSSS	SPOP	0.7062	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons