DegronMD

Uniprot ID: Q14584

Source protein: Zinc finger protein 266

Source gene: ZNF266

Class: DEG_SPOP_SBC_1

Location: 528:532

E3 ligase: SPOP

DEGRON score: 0.6008

ASA_SCORE: 56.08

COIL: 0.6904

CONS_SCORE: 0.5775

DSS_SCORE: 0.3489

HELIX: 0.078

FCONS_SCORE: 1.0147

RIG_SCORE: 0.6588

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K527T	TCGA-4R-AA8I	LIHC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.3056
p.K527T	DO49657	LIHC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.R536Q	TCGA-AA-3492	COAD	TCGA	AFSSS	DEG_SPOP_SBC_1	0.2222
p.R536Q	TCGA-AG-A002	READ	TCGA	AFSSS	DEG_SPOP_SBC_1	0.2222
p.R536Q	TCGA-DK-A6AW	BLCA	TCGA	AFSSS	DEG_SPOP_SBC_1	0.2222
p.R536Q	DO48566	BLCA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.2222
p.R536Q	DO8224	COAD	ICGC	AFSSS	DEG_SPOP_SBC_1	0.2222
p.R536Q	DO232532	PBCA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.2222
p.R536Q	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.2222
p.R536Q	ACH-002214	Lymphoma	CCLE	AFSSS	DEG_SPOP_SBC_1	0.2222
p.R536Q	BC-1	haematopoietic_and_lymphoid_tissue	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.2222
p.R540I	TCGA-E6-A1LX	UCEC	TCGA	AFSSS	DEG_SPOP_SBC_1	0.1111
p.R540I	DO222884	COCA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.1111
p.R540I	DO41020	UCEC	ICGC	AFSSS	DEG_SPOP_SBC_1	0.1111
p.S534F	TCGA-EE-A2MR	SKCM	TCGA	AFSSS	DEG_SPOP_SBC_1	0.2778
p.S534F	DO220889	MELA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.2778
p.S534F	DO222396	MELA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.2778
p.S534F	DO37819	SKCM	ICGC	AFSSS	DEG_SPOP_SBC_1	0.2778
p.S534F	SIDM00140	Melanoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.2778
p.S534F	ACH-000968	Skin Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.2778
p.S534F	COLO-792	skin	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.2778
p.K527Q	DO222798	COCA	ICGC	AFSSS	DEG_SPOP_SBC_1	0.3056
p.R541K	SIDM00527	Colorectal Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	0.0833
p.R541K	ACH-000935	Colon/Colorectal Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	0.0833
p.R541K	MDST8	large_intestine	COSMIC	AFSSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	413:417	AFSSS	SPOP	0.5892	More...
O75410	Transforming acidic coiled-coil-containing protein 1	DEG_SPOP_SBC_1	547:551	AFSSS	SPOP	0.8702	More...
O94823	Phospholipid-transporting ATPase VB	DEG_SPOP_SBC_1	535:539	AFSSS	SPOP	0.6502	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	405:409	AFSSS	SPOP	0.9658	More...
Q14584	Zinc finger protein 266	DEG_SPOP_SBC_1	528:532	AFSSS	SPOP	0.6008	More...
Q8WUY3	Protein prune homolog 2	DEG_SPOP_SBC_1	842:846	AFSSS	SPOP	0.9053	More...
Q9H4D5	Nuclear RNA export factor 3	DEG_SPOP_SBC_1	513:517	AFSSS	SPOP	0.6018	More...
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	DEG_SPOP_SBC_1	536:540	AFSSS	SPOP	0.9671	More...
Q9Y2K5	R3H domain-containing protein 2	DEG_SPOP_SBC_1	286:290	AFSSS	SPOP	0.8107	More...
Q8IZF4	Adhesion G-protein coupled receptor G5	DEG_SPOP_SBC_1	520:524	AFSSS	SPOP	0.683	More...
Q8N103	T-cell activation Rho GTPase-activating protein	DEG_SPOP_SBC_1	459:463	AFSSS	SPOP	0.9042	More...
Q8N7K0	Zinc finger protein 433	DEG_SPOP_SBC_1	290:294	AFSSS	SPOP	0.5748	More...
A8MVW0	Protein FAM171A2	DEG_SPOP_SBC_1	401:405	AFSSS	SPOP	0.9201	More...
Q9BXQ6	Transmembrane protein 121B	DEG_SPOP_SBC_1	112:116	AFSSS	SPOP	0.7062	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons