DegronMD - Q8N103(TAGAP)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D470E	TCGA-17-Z027	LUAD	TCGA	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.1389
p.F460V	TCGA-AA-A00N	COAD	TCGA	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation altering degron motif	0.5957
p.F460L	TCGA-AG-3731	READ	TCGA	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation altering degron motif	0.587
p.F460S	TCGA-CM-6161	COAD	TCGA	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation altering degron motif	0.6871
p.S469F	TCGA-FS-A1ZA	SKCM	TCGA	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.1667
p.P590H	TCGA-IB-7651	PAAD	TCGA	PPSY	ITCH	593:596	Mutation rewiring degron network	0.25
p.A467T	TCGA-VR-AA7D	ESCA	TCGA	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.2222
p.A599V	TCGA-XK-AAIW	PRAD	TCGA	PPSY	ITCH	593:596	Mutation rewiring degron network	0.25
p.A599V	ACH-001610	Brain Cancer	CCLE	PPSY	ITCH	593:596	Mutation rewiring degron network	0.25
p.P458H	DO230334	COCA	ICGC	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.3056
p.H464R	DO21571	LAML	ICGC	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.3056
p.H464Q	DO229041	LICA	ICGC	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.3056
p.A452V	DO219153	LUSC	ICGC	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.1389
p.P460L	DO220886	MELA	ICGC	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation altering degron motif	0.7582
p.M449I	DO220040	SARC	ICGC	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.0556
p.A604V	SIDM00075	Non-Cancerous	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM00530	Esophageal Carcinoma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM00301	Pancreatic Carcinoma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM00687	Gastric Carcinoma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM00360	Other Solid Cancers	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM00560	Gastric Carcinoma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM01257	Hepatocellular Carcinoma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM00289	B-Lymphoblastic Leukemia	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM00381	Cervical Carcinoma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM01781	Gastric Carcinoma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM00062	Hepatocellular Carcinoma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM01378	Ovarian Carcinoma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM00500	Colorectal Carcinoma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM01574	Plasma Cell Myeloma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM01756	Chronic Myelogenous Leukemia	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM01442	Glioma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.A604V	SIDM01619	Endometrial Carcinoma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1111
p.R453W	SIDM00602	Gastric Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.1667
p.R453W	ACH-000919	Gastric Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.1667
p.R453W	IM-95	stomach	COSMIC	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.1667
p.S464T	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.3056
p.S464T	ACH-000893	Lung Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.3056
p.S464T	NCI-H1651	lung	COSMIC	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.3056
p.E588K	SIDM00529	Breast Carcinoma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1944
p.E588K	ACH-000621	Breast Cancer	CCLE	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1944
p.E588K	MDA-MB-157	breast	COSMIC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.1944
p.A599T	SIDM01228	Melanoma	GDSC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.25
p.A599T	ACH-001024	Skin Cancer	CCLE	PPSY	ITCH	593:596	Mutation rewiring degron network	0.25
p.A599T	CHL-1	skin	COSMIC	PPSY	ITCH	593:596	Mutation rewiring degron network	0.25
p.S449L	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.0556
p.S449L	ACH-000869	Lung Cancer	CCLE	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.0556
p.S449L	NCI-H1568	lung	COSMIC	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.0556
p.P594T	ACH-000467	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	593:596	Mutation altering degron motif	0.7031
p.P594T	HCC-56	large intestine	COSMIC	PPSY	ITCH	593:596	Mutation altering degron motif	0.7031
p.P461S	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation altering degron motif	0.6752
p.R453L	DB	haematopoietic and lymphoid tissue	COSMIC	AFSSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAGAP

UniProt ID: Q8N103

Entrez ID: 117289

Protein name: T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TAGAP in