DegronMD

Uniprot ID: P27540

Source protein: Aryl hydrocarbon receptor nuclear translocator

Source gene: ARNT

Class: DEG_COP1_1

Location: 9:17

E3 ligase: COP1

DEGRON score: 0.9996

ASA_SCORE: 76.9667

COIL: 0.7967

CONS_SCORE: 0.2909

DSS_SCORE: 0.6031

HELIX: 0.1659

FCONS_SCORE: 1.196

RIG_SCORE: 0.703

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D13G	TCGA-UF-A7JT	HNSC	TCGA	EMTSDVPSL	DEG_COP1_1	0.6087
p.D13G	DO219090	HNSC	ICGC	EMTSDVPSL	DEG_COP1_1	0.6087
p.S26C	TCGA-XF-A9SH	BLCA	TCGA	EMTSDVPSL	DEG_COP1_1	0.0833
p.S26C	DO51913	BLCA	ICGC	EMTSDVPSL	DEG_COP1_1	0.0833
p.T11I	DO218139	BTCA	ICGC	EMTSDVPSL	DEG_COP1_1	0.8189
p.A2E	DO228986	LICA	ICGC	EMTSDVPSL	DEG_COP1_1	0.1389
p.I21T	SIDM02072	Colorectal Carcinoma	GDSC	EMTSDVPSL	DEG_COP1_1	0.2222
p.E9V	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	EMTSDVPSL	DEG_COP1_1	0.7693
p.E9V	NCI-H2066	lung	COSMIC	EMTSDVPSL	DEG_COP1_1	0.7693

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27540	Aryl hydrocarbon receptor nuclear translocator	DEG_COP1_1	9:17	EMTSDVPSL	COP1	0.9996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons