DegronMD

Uniprot ID: P27540

Source protein: Aryl hydrocarbon receptor nuclear translocator

Source gene: ARNT

Class: DEG_ODPH_VHL_1

Location: 499:512

E3 ligase: VHL

DEGRON score: 0.9345

ASA_SCORE: 100.1786

COIL: 0.6694

CONS_SCORE: 0.3569

DSS_SCORE: 0.7328

HELIX: 0.2913

FCONS_SCORE: 1.0557

RIG_SCORE: 0.7031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S521G	TCGA-CD-A4MG	STAD	TCGA	LAPRQQQQQTELDM	DEG_ODPH_VHL_1	0.0833
p.S521G	DO48009	STAD	ICGC	LAPRQQQQQTELDM	DEG_ODPH_VHL_1	0.0833
p.R516T	DO225366	BRCA	ICGC	LAPRQQQQQTELDM	DEG_ODPH_VHL_1	0.2222
p.D511Y	DO234347	ESAD	ICGC	LAPRQQQQQTELDM	DEG_ODPH_VHL_1	0.6214
p.A500E	DO229045	LICA	ICGC	LAPRQQQQQTELDM	DEG_ODPH_VHL_1	0.7701
p.M512T	SIDM02015	Colorectal Carcinoma	GDSC	LAPRQQQQQTELDM	DEG_ODPH_VHL_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27540	Aryl hydrocarbon receptor nuclear translocator	DEG_ODPH_VHL_1	499:512	LAPRQQQQQTELDM	VHL	0.9345	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons