DegronMD - Q9Y4P9(SPEF1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D179Y	TCGA-33-4566	LUSC	TCGA	PPAY	ITCH	169:172	Mutation rewiring degron network	0.1389
p.D179Y	DO233840	GACA	ICGC	PPAY	ITCH	169:172	Mutation rewiring degron network	0.1389
p.D179Y	DO26790	LUSC	ICGC	PPAY	ITCH	169:172	Mutation rewiring degron network	0.1389
p.Q143H	TCGA-AA-A00N	COAD	TCGA	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.2778
p.Q143H	DO9876	COAD	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.2778
p.Q143H	DO233130	GACA	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.2778
p.Q131H	TCGA-AP-A0LM	UCEC	TCGA	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation altering degron motif	0.647
p.Q131H	DO43306	UCEC	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation altering degron motif	0.647
p.R90H	TCGA-AX-A2HC	UCEC	TCGA	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation rewiring degron network	0.0833
p.R90H	DO41572	UCEC	ICGC	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation rewiring degron network	0.0833
p.A171T	TCGA-BF-A3DN	SKCM	TCGA	PPAY	ITCH	169:172	Mutation altering degron motif	0.6028
p.A171T	DO51239	SKCM	ICGC	PPAY	ITCH	169:172	Mutation altering degron motif	0.6028
p.Q64H	TCGA-D3-A2JP	SKCM	TCGA	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation rewiring degron network	0.0833
p.Q64H	DO47407	SKCM	ICGC	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation rewiring degron network	0.0833
p.P130T	TCGA-EE-A181	SKCM	TCGA	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation altering degron motif	0.7031
p.P130T	DO37444	SKCM	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation altering degron motif	0.7031
p.R163W	TCGA-UD-AAC1	MESO	TCGA	PPAY	ITCH	169:172	Mutation rewiring degron network	0.1667
p.G121D	DO230343	COCA	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.1389
p.A175V	DO222737	COCA	ICGC	PPAY	ITCH	169:172	Mutation rewiring degron network	0.25
p.A175V	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PPAY	ITCH	169:172	Mutation rewiring degron network	0.25
p.A175V	ACH-000353	Esophageal Cancer	CCLE	PPAY	ITCH	169:172	Mutation rewiring degron network	0.25
p.A175V	TE-15	oesophagus	COSMIC	PPAY	ITCH	169:172	Mutation rewiring degron network	0.25
p.M137K	DO228202	LICA	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation altering degron motif	0.6951
p.P85Q	DO229022	LICA	ICGC	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation rewiring degron network	0.2222
p.P180T	DO229035	LICA	ICGC	PPAY	ITCH	169:172	Mutation rewiring degron network	0.1111
p.P151Q	DO229009	LICA	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.0556
p.G140C	DO50902	LICA	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation altering degron motif	0.6489
p.G123S	DO229257	THCA	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.1944
p.V88L	DO229240	THCA	ICGC	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation rewiring degron network	0.1389
p.A122T	DO41199	UCEC	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.1667
p.N73D	SIDM01943	Colorectal Carcinoma	GDSC	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation altering degron motif	0.5821
p.R146Q	SIDM00376	B-Lymphoblastic Leukemia	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.1944
p.R146Q	ACH-000156	Leukemia	CCLE	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.1944
p.R146Q	MHH-CALL-4	haematopoietic and lymphoid tissue	COSMIC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.1944
p.P165Q	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	169:172	Mutation rewiring degron network	0.2222
p.P165Q	ACH-000924	Lung Cancer	CCLE	PPAY	ITCH	169:172	Mutation rewiring degron network	0.2222
p.P165Q	NCI-H2172	lung	COSMIC	PPAY	ITCH	169:172	Mutation rewiring degron network	0.2222
p.A145T	SIDM00973	Melanoma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.2222
p.A145T	SIDM00845	Burkitt's Lymphoma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.2222
p.A145T	SIDM00311	Mesothelioma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.2222
p.A145T	SIDM00854	Burkitt's Lymphoma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.2222
p.A145T	SIDM00032	Bladder Carcinoma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.2222
p.A145T	SIDM00793	Burkitt's Lymphoma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.2222
p.A145T	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.2222
p.A145T	SIDM00808	Burkitt's Lymphoma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.2222
p.A145T	SIDM01254	Burkitt's Lymphoma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.2222
p.P151S	SIDM00569	Osteosarcoma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.0556
p.P151S	ACH-002178	Bone Cancer	CCLE	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.0556
p.P151S	NY	bone	COSMIC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	128:141	Mutation rewiring degron network	0.0556
p.L77P	SIDM00142	Endometrial Carcinoma	GDSC	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation altering degron motif	0.7582
p.L77P	ACH-000864	Endometrial/Uterine Cancer	CCLE	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation altering degron motif	0.7582
p.L77P	COLO-684	endometrium	COSMIC	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation altering degron motif	0.7582
p.V88M	SIDM00596	Endometrial Carcinoma	GDSC	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation rewiring degron network	0.1389
p.V88M	ACH-001517	Endometrial/Uterine Cancer	CCLE	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation rewiring degron network	0.1389
p.V88M	HEC-1	endometrium	COSMIC	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation rewiring degron network	0.1389
p.P180S	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	169:172	Mutation rewiring degron network	0.1111
p.P170A	SIDM00276	Biliary Tract Carcinoma	GDSC	PPAY	ITCH	169:172	Mutation altering degron motif	0.7503
p.P170A	ACH-002237	Bile Duct Cancer	CCLE	PPAY	ITCH	169:172	Mutation altering degron motif	0.7503
p.P170A	ETK-1	biliary tract	COSMIC	PPAY	ITCH	169:172	Mutation altering degron motif	0.7503
p.H71Y	SIDM00118	Colorectal Carcinoma	GDSC	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation rewiring degron network	0.2778
p.H71Y	ACH-001081	Colon/Colorectal Cancer	CCLE	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation rewiring degron network	0.2778
p.H71Y	HCC2998	large intestine	COSMIC	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation rewiring degron network	0.2778
p.N81K	SIDM00867	Glioblastoma	GDSC	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation altering degron motif	0.5806
p.N81K	ACH-000863	Brain Cancer	CCLE	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation altering degron motif	0.5806
p.N81K	DBTRG-05MG	central nervous system	COSMIC	NRKVLKRLN	DEG_APCC_DBOX_1	73:81	Mutation altering degron motif	0.5806

Kaplan plot for SPEF1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPEF1

UniProt ID: Q9Y4P9

Entrez ID: 25876

Protein name: Sperm flagellar protein 1

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SPEF1 in