DegronMD

Uniprot ID: Q9Y4P9

Source protein: Sperm flagellar protein 1

Source gene: SPEF1

Class: DEG_APCC_DBOX_1

Location: 73:81

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7033

ASA_SCORE: 77.1333

COIL: 0.3188

CONS_SCORE: 0.7591

DSS_SCORE: 0.1605

HELIX: 0.6644

FCONS_SCORE: 1.2169

RIG_SCORE: 0.8421

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R90H	TCGA-AX-A2HC	UCEC	TCGA	NRKVLKRLN	DEG_APCC_DBOX_1	0.0833
p.R90H	DO41572	UCEC	ICGC	NRKVLKRLN	DEG_APCC_DBOX_1	0.0833
p.Q64H	TCGA-D3-A2JP	SKCM	TCGA	NRKVLKRLN	DEG_APCC_DBOX_1	0.0833
p.Q64H	DO47407	SKCM	ICGC	NRKVLKRLN	DEG_APCC_DBOX_1	0.0833
p.P85Q	DO229022	LICA	ICGC	NRKVLKRLN	DEG_APCC_DBOX_1	0.2222
p.V88L	DO229240	THCA	ICGC	NRKVLKRLN	DEG_APCC_DBOX_1	0.1389
p.N73D	SIDM01943	Colorectal Carcinoma	GDSC	NRKVLKRLN	DEG_APCC_DBOX_1	0.5821
p.L77P	SIDM00142	Endometrial Carcinoma	GDSC	NRKVLKRLN	DEG_APCC_DBOX_1	0.7582
p.L77P	ACH-000864	Endometrial/Uterine Cancer	CCLE	NRKVLKRLN	DEG_APCC_DBOX_1	0.7582
p.L77P	COLO-684	endometrium	COSMIC	NRKVLKRLN	DEG_APCC_DBOX_1	0.7582
p.V88M	SIDM00596	Endometrial Carcinoma	GDSC	NRKVLKRLN	DEG_APCC_DBOX_1	0.1389
p.V88M	ACH-001517	Endometrial/Uterine Cancer	CCLE	NRKVLKRLN	DEG_APCC_DBOX_1	0.1389
p.V88M	HEC-1	endometrium	COSMIC	NRKVLKRLN	DEG_APCC_DBOX_1	0.1389
p.H71Y	SIDM00118	Colorectal Carcinoma	GDSC	NRKVLKRLN	DEG_APCC_DBOX_1	0.2778
p.H71Y	ACH-001081	Colon/Colorectal Cancer	CCLE	NRKVLKRLN	DEG_APCC_DBOX_1	0.2778
p.H71Y	HCC2998	large_intestine	COSMIC	NRKVLKRLN	DEG_APCC_DBOX_1	0.2778
p.N81K	SIDM00867	Glioblastoma	GDSC	NRKVLKRLN	DEG_APCC_DBOX_1	0.5806
p.N81K	ACH-000863	Brain Cancer	CCLE	NRKVLKRLN	DEG_APCC_DBOX_1	0.5806
p.N81K	DBTRG-05MG	central_nervous_system	COSMIC	NRKVLKRLN	DEG_APCC_DBOX_1	0.5806

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4P9	Sperm flagellar protein 1	DEG_APCC_DBOX_1	73:81	NRKVLKRLN	APC,CDC20,FZR1	0.7033	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons