DegronMD

Uniprot ID: Q9Y4P9

Source protein: Sperm flagellar protein 1

Source gene: SPEF1

Class: DEG_ODPH_VHL_1

Location: 128:141

E3 ligase: VHL

DEGRON score: 0.9486

ASA_SCORE: 69.0786

COIL: 0.7386

CONS_SCORE: 0.3658

DSS_SCORE: 0.6248

HELIX: 0.1191

FCONS_SCORE: 1.0079

RIG_SCORE: 0.6522

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q143H	TCGA-AA-A00N	COAD	TCGA	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.2778
p.Q143H	DO9876	COAD	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.2778
p.Q143H	DO233130	GACA	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.2778
p.Q131H	TCGA-AP-A0LM	UCEC	TCGA	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.647
p.Q131H	DO43306	UCEC	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.647
p.P130T	TCGA-EE-A181	SKCM	TCGA	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.7031
p.P130T	DO37444	SKCM	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.7031
p.G121D	DO230343	COCA	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.1389
p.M137K	DO228202	LICA	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.6951
p.P151Q	DO229009	LICA	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.0556
p.G140C	DO50902	LICA	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.6489
p.G123S	DO229257	THCA	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.1944
p.A122T	DO41199	UCEC	ICGC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.1667
p.R146Q	SIDM00376	B-Lymphoblastic Leukemia	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.1944
p.R146Q	ACH-000156	Leukemia	CCLE	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.1944
p.R146Q	MHH-CALL-4	haematopoietic_and_lymphoid_tissue	COSMIC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.1944
p.A145T	SIDM00973	Melanoma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.2222
p.A145T	SIDM00845	Burkitt's Lymphoma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.2222
p.A145T	SIDM00311	Mesothelioma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.2222
p.A145T	SIDM00854	Burkitt's Lymphoma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.2222
p.A145T	SIDM00032	Bladder Carcinoma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.2222
p.A145T	SIDM00793	Burkitt's Lymphoma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.2222
p.A145T	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.2222
p.A145T	SIDM00808	Burkitt's Lymphoma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.2222
p.A145T	SIDM01254	Burkitt's Lymphoma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.2222
p.P151S	SIDM00569	Osteosarcoma	GDSC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.0556
p.P151S	ACH-002178	Bone Cancer	CCLE	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.0556
p.P151S	NY	bone	COSMIC	LAPQDGSGYMDVGV	DEG_ODPH_VHL_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPQDGSGYMDVGV

Degron related mutations and impact score

Drug responses associated with SPEF1 mutations

All proteins holding degron of LAPQDGSGYMDVGV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4P9	Sperm flagellar protein 1	DEG_ODPH_VHL_1	128:141	LAPQDGSGYMDVGV	VHL	0.9486	More...